Authors: Roseanna Presutti, Janet Nguyen, Amanda Hird, Alysa Fairchild, Mark Clemons, Marc Kerba, Arjun Sahgal and Edward Chow
Abstract: Bone metastases are a common consequence of many malignancies. Few clinical trials have evaluated quality of life (QOL) as an endpoint in studies directed to medical or radiotherapy interventions for bone metastases. Given the lack of well-developed bone metastases specific QOL instruments, our group initiated the development of a bone metastases questionnaire in accordance with the European Organization for Research and Treatment of Cancerís (EORTC) module development guidelines. The module is currently in the final stage of development (international field testing) and is available for clinical use through the EORTC. This paper addresses previous clinical trials in patients with bone metastases receiving palliative RT, and describes the QOL assessments completed. The development of the EORTC bone metastases module and future research directions are also discussed.