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Apolipoproteins: Regulatory Functions, Health Effects and Role in Disease
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Editors: Adrik D. Sidorov and Misha Y. Nikitin
Book Description:
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues. In this book, the authors present current research in the study of the regulatory functions, health effects and role in disease of apolipoproteins. Topics include macrophages, apolipoproteins, steroid hormones and molecular mechanisms of cell proliferation; formation of discoidal apolipoprotein A-1 lipid bound complexes; the role of apolipoprotein E in cardiovascular and renal disease; the functional variants and mutations of the apolipoprotein A5 gene in human pathology; and regulation of FGF-1 of ApoE/HDL generation in astrocytes. (Imprint: Nova Biomedical)

Table of Contents:
Preface pp. i-x

Macrophages, Lipo(Apo)Proteins, Steroid Hormones, and Molecular Mechanisms of Cell Proliferation
(L.E. Panin, Scientific Research Institute of Biochemistry SB RAMS, Novosibirsk, Russia) pp. 1-34

Current Concepts on the Formation of Discoidal Apolipoprotein A-I Lipid Bound Complexes: From Picket Fences to a Double-Belt Model via Inter-Ring Rotation of Apolipoprotein A-I Monomers
(Thomas R. Caulfield, Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, USA) pp. 35-55

Understanding the Role of Apolipoprotein E in Cardiovascular and Renal Diseases
(C.M. Balarini, I.B.S. Gomes, E.C. Vasquez, S.S. Meyrelles, A.L. Gava, Federal University of Espirito Santo, Vitoria, ES, Brazil, and others) pp. 57-74

Role of Functional Variants and Mutations of the Apolipoprotein A5 Gene in Human Pathology
(Balázs Duga, Béla I.Melegh, Katalin Sümegi, Anita Maász, Péter Kisfali, Katalin Komlósi, Béla Melegh B., Department of Medical Genetics, University of Pécs; and Szentágothay Research Center, Pécs, Hungary) pp. 75-92

Mechanism of Antiinflammatory Action of the High Density Lipoproteins and Apolipoprotein A-I
(L. Polyakov, D. Sumenkova, L. Panin, Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Science, Russia, Novosibirsk, Russia) pp. 93-109

Apolipoprotein A-I Motifs in Discoidal High Density Lipoproteins Influence Lecithin: Cholesterol Acyltransferase Activity
(Alexander D. Dergunov, National Research Centre for Preventive Medicine, Moscow, Russia) pp. 111-130

Regulation by FGF-1 of ApoE/HDL Generation in Astrocytes
(Jinichi Ito, Makoto Michikawa, Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan) pp. 131-143

Index pp. 145-154

      Protein Biochemistry, Synthesis, Structure and Cellular Functions
      Protein Science and Engineering
   Binding: Hardcover
   Pub. Date: 2012- October
   Pages: 164, 7 x 10 (NBC - R)
   ISBN: 978-1-62257-484-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Apolipoproteins: Regulatory Functions, Health Effects and Role in Disease