Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Proteins » Serpins and Protein Kinase Inhibitors: Novel Functions, Structural Features and Molecular Mechanisms Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Theory of Literature
$270.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to PAI-1 and the Diet-Induced Obesity Phenotype: Background Effects and Inbreeding pp.183-198
Tell A Friend
 
Tell someone you know about this product.
PAI-1 and the Diet-Induced Obesity Phenotype: Background Effects and Inbreeding pp.183-198 $100.00
Authors:  (Bart M. De Taeye, Tatiana Novitskaya, and Douglas E. Vaughan, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN)
Abstract:
The effect of PAI-1 deficiency on the development of obesity and insulin resistance is controversial. Published reports have suggested that PAI-1 deficiency can protect or have no effect on the development of diet-induced obesity in mice. To further investigate these apparent discrepant findings, PAI-1 deficient and wild-type C57BL/6J littermate mice were fed a diet high in fat or a regular diet and this for either 12 or 30 weeks. The development of obesity and the degree of insulin resistance was analyzed. PAI-1 deficient animals were not protected from the development of obesity or insulin resistance. Analysis of the change in weight and percentage body fat for the individual mice revealed that even though mice were littermates, they showed significant variability in the degree of obesity development and adipose tissue accumulation within the same group, in agreement with findings from studies focusing on the effects of epigenetic changes in diet-induced obesity in littermate mice. As such, while our data confirm that PAI-1 genotype does not influence the development of diet-induced obesity and diabetes, they help explaining so far contradicting data. In conclusion, PAI-1 inhibition could be important to prevent complications associated with obesity but not the development of obesity itself. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

PAI-1 and the Diet-Induced Obesity Phenotype: Background Effects and Inbreeding pp.183-198