Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Proteins » Leptin: Hormonal Functions, Dysfunctions and Clinical Uses Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Doxycycline: Medical Uses and Effects
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Role of Leptin in the Activation of the Immune System pp. 71-88
Tell A Friend
Tell someone you know about this product.
Role of Leptin in the Activation of the Immune System pp. 71-88 $100.00
Authors:  (Patricia Fernández-Riejos, Souad Najib, José Santos-Alvarez, Consuelo Martín-Romero, Antonio Pérez-Pérez, Carmen González-Yanes, Víctor Sánchez-Margalet, Department of Clinical Biochemistry, Virgen Macarena University Hospital, University of Seville, Spain)
Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by the adipocyte, with a variety of physiological roles related with the control of metabolism and energy homeostasis. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone leptin has been shown to regulate the immune response, innate and adaptative response, both in normal as well as in pathological conditions. The role of leptin in regulating immune response has been assessed in vitro as well as in clinical studies. It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility. On the other hand, leptin can promote autoreactivity. As a pro-inflammatory adipokine, it can induce T helper 1 cells and may contribute to the development and progression of autoimmune responses. A number of studies have implicated a role of leptin in the pathogenesis of several autoimmune diseases, including type 1 diabetes, inflammatory bowel disease, and possibly rheumatoid arthritis. This aspect is also of interest in relation to the well-known gender bias in susceptibility to autoimmunity. Autoimmune diseases are frequently more prevalentin females, and females are relatively hyperleptinemic. The modulation of circulating leptin levels has a pivotal role on some inflammatory and autoimmune conditions. 

Available Options:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

Role of Leptin in the Activation of the Immune System pp. 71-88