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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.Myelin Basic Protein
05.New Research on Genomic Instability
06.Developmental Gene Expression Regulation
07.Lecture Notes on Computational Mutation
08.Fragile Sites: New Discoveries and Changing Perspectives
09.Progress in Stem Cell Applications
10.Genetic Vectors Research Focus
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Focus on Sickle Cell Research
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Editors: Plasmar, Ralph L.
Book Description:
Sickle cell anemia is an inherited blood disorder, characterized primarily by chronic anemia and periodic episodes of pain and occurring in approximately 1 in every 400 African-American infants born in the United States each year. Individuals of Mediterranean, Arabian, Caribbean, South and Central American, and East Indian ancestry can also be affected. The underlying problem involves hemoglobin, a component of the red cells in the blood. The hemoglobin molecules in each red blood cell carry oxygen from the lungs to the body organs and tissues and bring back carbon dioxide to the lungs. In sickle cell anemia, the hemoglobin is defective. After the hemoglobin molecules give up their oxygen, some of them may cluster together and form long, rod-like structures. These structures cause the red blood cells to become stiff and to assume a sickle shape. Unlike normal red cells, which are usually smooth and donut-shaped, the sickled red cells cannot squeeze through small blood vessels. Instead, they stack up and cause blockages that deprive the organs and tissue of oxygen-carrying blood. This process produces the periodic episodes of pain and ultimately can damage the tissues and vital organs and lead to other serious medical problems. Unlike normal red blood cells, which last about 120 days in the bloodstream, sickled red cells die after only about 10 to 20 days. Because they cannot be replaced fast enough, the blood is chronically short of red blood cells, a condition called anemia. Sickle cell anemia is caused by an error in the gene that tells the body how to make hemoglobin. The defective gene tells the body to make the abnormal hemoglobin that results in deformed red blood cells. This book gathers the latest research in this important field.

Please click on a chapter below to purchase separately

Chapter 1 - Energy And Protein Metabolism In Sickle Cell Disease: Evidence Of Aberrations
Authors / Editors: Buchholz, Andrea C. and Buchowski, Maciej S. (Vanderbilt University Medical Center and Department of Family and Community Medicine, Meharry Medical College Nashville, TN)

Chapter 2 - Cerebral Vasculopathy In Sickle Cell Anemia: Diagnosis, Therapeutic Clinical Trials And The Potential For Prevention (pp. 19-58)
Authors / Editors: Powars, Darleen R. (LAC+USC Medical Center, Los Angeles, CA)

Chapter 3 - Stroke In Sickle Cell Anemia In The Mid-Southern Region Of Turkey (pp. 59-67)
Authors / Editors: Kilinç, Yurdanur; Şaşmaz, Ilgen; Antmen, Bülent; Kozanoglu, H. Hayriye; Soyupak, Süreyya; Altunbaşak, Şakir (Çukurova University, Adana, Turkey)

Chapter 4 - Stroke In Sickle Cell Disease (pp. 69-80)
Authors / Editors: Arshad, Jawad A.; Klausner, Howard A.; Lewandowski, Christopher (Henry Ford Hospital, Detroit, MI)

Chapter 5 - Sickle Cell Disease And Stroke: Using Transcranial Dopplers And Other Neurodiagnostic Tests To Protect The Brain
Authors / Editors: Switzer, Jeffrey A. and Adams, Robert J. (Medical College of Georgia)

Chapter 6 - Sickle Cell Crisis And Malaria – The Band 3 Connection (pp. 99-112)
Authors / Editors: Kennedy, J. Randall (Manatee Memorial Hospital)

Chapter 7 - Multiple Myeloma In Sickle Cell Syndromes (pp. 113-124)
Authors / Editors: Andreas, Kaloterakis and Anna, Filiotou (University of Athens School of Medicine, Second Department of Medicine at Hippocration Hospital, Athens, Greece)

Chapter 8 - Sickle Cell Hemoglobinopathy And Sudden Death (pp. 125-130)
Authors / Editors: de la Grandmaison, G. Lorin (University R. Descartes, Paris;Raymond Poincaré Hospital, France)

Chapter 9 - Global Left Ventricular Performance In Sickle Cell Anemia During Childhood As Determined By Echocardiography
Authors / Editors: Seliem, Mohamed A. (Aramco Dhahran Health Center, Saudi Arabia)

Chapter 10 - Sickle Cell Disease: Laboratory Investigations And Hemoglobin Study (pp. 137-155)
Authors / Editors: Wajcman, Henri (Hôpital H. Mondor, Créteil, France)

Chapter 11 - Renal Medullary Carcinoma: The Seventh Sickle Cell Nephropathy
Authors / Editors: Khan, Ali Nawaz (North Manchester General Hospital, Crumpsall, Manchester)

   Binding: Hardcover
   Pub. Date: 2004
   ISBN: 1-59033-920-7
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

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