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Monoclonal Antibodies: New Research
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Editors: Simmons, Marie A.
Book Description:
This new and important international source of information beings together leading-edge research dedicated to monoclonal antibodies. Monoclonal antibodies (MAbs) are: antibodies of exceptional purity and specificity; components of the immune system; able to recognize and bind to a specific antigen. Monoclonal antibodies are currently utilized in many diagnostic procedures, including: measuring protein and drug levels in serum; typing tissue and blood; identifying infectious agents; identifying clusters of differentiation for the classification and follow-up therapy of leukemias and lymphomas; identifying tumor antigens and auto-antibodies; identifying the specific cells involved in the immune response; identifying and quantifying hormones. For example, monoclonal antibodies (MABs or MOABs) work on cancer cells in the same way natural antibodies work, by identifying and binding to the target cells. They then alert other cells in the immune system to the presence of the cancer cells. MABs are specific for a particular antigen-one designed for a B-cell lymphoma will not work on cells for ovarian cancer cells for example.

Table of Contents:
Preface; Binding Properties of Antibodies to Bacterial Capsular Polysialic Acids: Implications to Vaccination Against Meningitis (Jukka Häyrinen, University of Kuopio, Finland)pp.1-26; A Monoclonal Antibody Against α-Enolase Plasminogen Receptor with Inhibitory Properties: A Useful Tool to Study Pericellular Plasminogen Activation (Roser López-Alemany, Institut de Recerca Oncologica, Spain)pp.27-50; Quantitative Analysis of Antibody-Antigen Interactions Using Immobilized Ligands: Kinetic Exclusion Assays Are More Accurate than Surface Plasmon Resonance (Robert C. Blake II, University of Louisiana and Diane A. Blake, Tulane University Health Sciences Center)pp.51-78; ABCIXIMAB (Rena F. Burghli et al., University of Medicine and Dentistry of New Jersey)pp.79-104; Trastuzumab: The Experience of the Hellenic Cooperative Oncology Group (HeCOG) (Christos Christodoulou et al., “Henry Dunant” Hospital, Greece)pp.105-142; Dimenthyl Sulfoxide-induced Stimulation on Monoclonal Antibody Production is Regulated by P38 Mitogen-activated Protein Kinase in Hybridoma Cells (Wai Lam W. Ling and Liang Deng, Schering-Plough Research Institute)pp.143-150; Effect of Anti-Mouse Interleukin-6 Receptor Antibody in Autoimmune Mouse Models (Masahiko Mihara et al., Chugai Pharmaceutical Co., Ltd., Japan)pp.151-163; Index.

   Binding: Softcover
   Pub. Date: 2005
   ISBN: 1-59454-247-3
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Monoclonal Antibodies: New Research