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Molecular Aspects of G Protein-Coupled Receptors: Interacting Proteins and Function
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Editors: Franciso Ciruela (Dept. Patologia i Terapèutica Experimental, Univ. of Barcelona, Barcelona, Spain), Rafael Lujan (Dept. Ciencias Medicas, Univ. de Castilla-La Mancha, Campus Biosanitario, Albacete, Spain)
Book Description:
In the recent years studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton.

The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.

Table of Contents:
Preface

Chapter I - Adenosine Receptors Interacting Proteins (ARIPs);
pp. 1-27
(Javier Burgueño, In vitro Screening and Assay Development, Laboratoris Dr. Esteve, Barcelona, Spain, Laia Canela, Dept. de Bioquímica i Biologia Molecular, IDIBAPS- Universitat de Barcelona, Barcelona, Spain, Jorge Gandía, Unitat de Farmacologia, Dept. Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL-Universitat de Barcelona, L’Hospitalet de Llobregat, Spain)

Chapter II - Adrenoreceptors and their G Protein-Coupled Receptors Interacting Proteins (GIPs): Roles in Receptor Signaling and Regulation; pp. 29-60
(Petronila Penela, Dept. de Biología Molecular, Centro de Biología Molecular “Severo Ochoa”, Consejo Superior de Investigaciones Científicas, Univ. Autónoma de Madrid, Madrid, Spain)

Chapter III - 5-HT Receptor-Interacting Proteins: From Fine-Tuning of Signalling to Novel Therapeutic Targets in Psychiatric Diseases; pp. 61-110
(Philippe Marin, Marilyne Labasque, Sophie Gavarini, NRS UMR 5203, Montpellier, France; INSERM, Montpellier, France; Univ Montpellier I, Montpellier, France; Univ Montpellier II, Montpellier, France, Institut de Génomique Fonctionnelle, Dept. de Neurobiologie, Montpellier, Montpellier Cedex)

Chapter IV - Muscarinic Receptor-Associated Proteins: More Than Just An Interaction Between Proteins; pp. 111-145
(Dasiel O. Borroto-Escuela, Univ. Politécnica de Catalunya, Ingeniería Química, Terrassa, Spain, Francisco Ciruela, Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Univ. de Barcelona, L’Hospitalet de Llobregat, Spain)

Chapter V - Protein Interactions in Dopamine Receptor Signalling: From Receptor Complexes to Brain Disease; pp. 147-167
(Nadine Kabbani, Dept. of Neuroscience, Institute Pasteur, Paris cedex, France)

Chapter VI - Novel Interacting Partners Regulating Opioid Receptor Signalling; pp. 169-207
(Zafiroula Georgoussi, Laboratory of Cellular Signaling and Molecular Pharmacology, Institute of Biology, National Center for Scientific Research “Demokritos”, Aghia Paraskevi, Athens, Greece)

Chapter VII - Molecular Determinants Governing Protein-Protein Interactions with the Parathyroid Hormone 1 Receptor; pp. 209-238
(Matthew J. Mahon, Dept. of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA)

Chapter VIII - GABAB Receptor-Associated Protein: Understanding the Mechanisms of Neuronal Signaling; pp. 239-262
(Rafael Luján, Dept. de Ciencias Médicas, Facultad de Medicina-CRIB, Universidad de Castilla-La Mancha, Campus Biosanitario, Almansa, Albacete, Spain, Francisco Ciruela, Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Univ. de Barcelona, L’Hospitalet de Llobregat, Spain)

Chapter IX - Binding Partners of Metabotropic Glutamate Receptors; pp. 263-292
(Ralf Enz, Emil-Fischer-Zentrum, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstrasse, Erlangen, Germany)

Index

   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 1-60021-915-2
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Molecular Aspects of G Protein-Coupled Receptors: Interacting Proteins and Function