Book Description:
This book describes several ways to improve drug localization and to increase anti-tumor efficacy, such as through drug modifications and through the development of anti-tumor drug delivery systems. Anticancer drugs have little or no specificity, resulting in low tumor concentrations, systemic toxicity and severe side effects. The pharmacological inhibitors of Hsp90, a major cytosolic chaperone, are examined in this book since they are often used in anticancer therapy. Furthermore, polyphenols, an anti-cancer agent which constitutes the most abundant group of antioxidants of normal human food, is discussed as well. Polyphenols protect against oxidative stress and their associated pathologies include inflammation, cancer and coronary heart diseases. Thus, they play an important role as an anticancer agent. Finally, metal-based antitumor drugs, which play an essential role in clinics today are reviewed. In particular, ruthenium compounds as promising alternatives to platinum-based anticancer drugs.

Table of Contents:
Preface

Research and Review Studies

Micro- and Nano-Particulate Drug Delivery Systems for Cancer Treatment
(Jose L. Arias - Dept. of Pharmacy and Pharmaceutical Technology, Univ. of Granada, Granada, Spain)pp.1-86

Geldanamycin Derivatives as Promising Anticancer Drugs: Therapy via Hsp90 Inhibition
(Alexander E. Kabakov - Dept. of Radiation Biochemistry, Medical Radiology Research Center, Obninsk, Russia)pp.87-114

Synergistic Antitumor Activity of Metronomic Dosing Chemotherapy in Combination with Liposomal Anticancer Drug
(Tatsuhiro Ishida, Hiroshi Kiwada - Dept. of Pharmacokinetics and Biopharmaceutics, Univ. of Tokushima, Sho-machi, Tokushima, Japan)pp.115-144

Organotin Polyethers as Anticancer Drugs
(Charles E. Carraher, Jr., Michael R. Roner, Girish Barot - Florida Atlantic Univ., Dept. of Chemistry and Biochemistry, Boca Raton, FL and others)pp.145-170

Studies on Anticancer Agents: Phenolic Compounds and their Pharmacological Activity
(Maria Dolors Pujol, Isabel Sanchez - Laboratori de Quimica Farmaceutica, Univ. de Barcelona, Barcelona, Spain) pp.171-194

Design of Novel Anticancer Drugs Utilizing Busulfan for Optimizing Pharmacological Properties and Pattern Recognition Techniques for Elucidation of Clinical Efficacy
(Ronald Bartzatt - Univ. of Nebraska, Chemistry Department, Omaha, NE, USA)pp.195-210

Analysis of Associations Among Novel Property Descriptors and their Capacity in Determining Clinical Efficacy by Utilizing Pattern Recognition Technigues
(Ronald Bartzatt - Univ. of Nebraska, Chemistry Department, Omaha, NE, USA)pp.211-226

Insights into the Mode of Action of Investigational Ruthenium(III) Cytotoxins from Electrochemical and Biological Studies
Erwin Reisner - Univ. of Oxford, Inorganic Chemistry Laboratory, Oxford, UK)pp.227-238

Short Communication

Marina Crystal Minerals(MCM) Induce Apoptosis of Human Metastatic Breast Cancer MDA-MB-231 Cells In Vitro
(Mamdooh Ghoneum, Takeshi Ogura, Sastry Gollapudi- Dept. of Otolaryngology, Drew Univ. of Medicine and Science, Los Angeles, CA, USA and others)pp.239-248

Index pp.249-271