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Beneficial Effects of Perhexiline in Cardiovascular Disease States
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Authors: Yuliy Y. Chirkov, Aaron L. Sverdlov and John D. Horowitz (The University of Adelaide, Australia) 
Book Description:
Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as a prophylactic anti-anginal drug in the late 1960s. It was initially a popular and effective treatment for angina, having the almost unique property compared to other agents available at that time, of not inducing reductions in blood pressure or heart rate. Despite the initial success, its use diminished markedly due to the occurrence during long-term therapy of poorly understood side effects (neurotoxicity and hepatotoxicity), which later were shown to be associated with high plasma concentrations of perhexiline, occurring in patients with relatively slow hepatic metabolism of the drug. However, therapeutic plasma monitoring and associated dose adjustments have led to perhexiline's reintroduction into clinical practice. This new book discusses the benefits of perhexiline in the treatment of cardiovascular disease.

Imprint: Nova Biomedical




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Table of Contents:
Introduction

Chapter 1. Clinical Applications of Perhexiline

Stable and Unstable Angina Pectoris

Aortic Stenosis

Heart Failure

Chapter 2. Pharmacokinetics and Toxicity of Perhexiline

Chapter 3. Pharmacology of Perhexiline

Ion Channels

Metabolic Shift

Interactions with NO Signaling Pathway

NO Resistance in Cardiovascular Disease States

Mechanisms of NO Resistance

Amelioration of Platelet NO Resistance by Perhexiline

Oxidative Stress and Inflammation

Chapter 4. Conclusion and Future Perspectives

Index

   Series:
      Cardiology Research and Clinical Developments
   Binding: Softcover
   Pub. Date: 2010
   Pages: 5.5 x 8.5
   ISBN: 978-1-61668-977-3
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Beneficial Effects of Perhexiline in Cardiovascular Disease States