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Bicuspid Aortic Valve: Diagnosis, Surgical Treatment and Complications
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Editors: Anthony Chapman
Book Description:
Bicuspid aortic valve (BAV) is the most common congenital pathology of the aortic valve occurring in 0.5-2% of the general population and frequently requiring surgical management after the fourth decade of life. From the etiology to the surgical management of BAV is analyzed. Other chapters review genome-wide association studies, linkage analyses and next-generation sequencing studies, which are beginning to build a more comprehensive picture of the genetic bases of BAV. The prospects for developing tools for genetic screening of families and for risk stratification are explored as well, including the future steps which are necessary for the creation of an individualized approach to managing BAV. The last chapter is a review of the present understanding of ascending thoracic aortic aneurysm pathogenesis. The genetic basis and basic pathology underlying BAV and ascending thoracic aortic aneurysms are discussed as well, and are compared to known mechanisms underlying other aortopathologies. (Imprint: Nova Biomedical)

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Table of Contents:
Preface pp.vii-x

Bicuspid Aortic Valve Syndrome: From the Etiology to the Surgical Strategies of Treatment
(Paolo Nardi, Marco Russo, Antonio Pellegrino, and Luigi Chiariello, Policlinico Universitario Tor Vergata, Tor Vergata University of Rome, Rome, Italy)pp.1-22

Genetic Influences on Phenotype in Bicuspid Aortic Valve: Screening, Diagnosis and Prognosis
(Catherine Francis and John Pepper, NIHR Cardiovascular BRU, Royal Brompton Hospital; National Heart & Lung Institute, Imperial College London and Institute of Cardiovascular Medicine and Science, London/Liverpool, England)pp.23-54

Genetic Basis, Pathogenesis and Histopathology of Aortopathy in Bicuspid Aortic Valve and Marfan Syndrome
(Junfeng Yana, Ann-Cathrin Lehsaua, Pamela Lazar-Karstena, Detlev Schult-Baduschea, Luc Mertensb, Bart L. Loeysc, Salah A. Mohameda, aDepartment of Cardiac and Thoracic Vascular Surgery, UK SH-Campus Luebeck, Luebeck, Germany; bThe Hospital for Sick Children, Toronto, Candada; cCenter of Medical Genetics, University of Antwerp and University Hospital of Antwerp, Belgium, Radhoud University, Nijmegen, The Netherlands)pp.55-82

Index pp.83-90

   Series:
      Congenital Disorders - Laboratory and Clinical Research
   Binding: Softcover
   Pub. Date: 2015 - 3rd Quarter
   Pages: 100. 6x9 - (NBC-R)
   ISBN: 978-1-63482-786-7
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Bicuspid Aortic Valve: Diagnosis, Surgical Treatment and Complications