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Estrogen and Myocardial Infarction
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Authors: Jiang Hong, Chen Jing, He Bo, and Lu Zhi-bing (Department of Cardiology, Renmi Hospital, Wuhan University, WuhanCChina) 
Book Description:
The higher cardiovascular risk in men and post-menopausal women implies a protective action of estrogen. A large number of experimental studies have provided strong evidence indicating that estrogen has protective effect in the process of myocardial infarction (MI). Estrogen may prevent deterioration of cardiac function post-MI through improving heart failure of cadiocyte biology and also through mediating arrhythmia. The alternations by estrogen in immune function, apoptosis and endothelial progenitor cells after MI may be the most important mechanisms for cadiocyte survival. For the control of cardiac hypertrophy, estrogen acts as both a potent vasodilator and a direct mediator for cadiocyte. The major mechanisms underlying arrhythmia effect may involve affecting neural remodeling, electrical remodeling and structural remodeling.

In this new book, the authors mainly focus on the current mechanisms underlying the estrogen effects after MI through genomic pathway and non-genomic pathway. A further understanding of estrogen and estrogen receptors function and regulation may lead to the development of highly specific prevention and treatment of cardiovascular diseases.

Table of Contents:
Preface

1. Estrogen and Heart Failure Post-MI

1.1 Estrogen and Inflammation

1.2 Estrogen and Apoptosis

1.2.1 The Effect of Estrogen on Anti-Apoptosis System

1.2.2 The Effect of Estrogen on Apoptosis System

1.3 Estrogen and Endothelial Progenitor Cell (EPCs)

1.4 Estrogen and Cardiac Hypertrophy

1.4.1 Role of ERs in Cadiocyte Hypertrophy

1.4.2 Anti-Hypertrophy Pathway Induced by Estrogen

2. Estrogen and Arrhythmia Post-MI

2.1 Estrogen and Neural Remodeling

2.2 Estrogen and Electrical Remodeling

2.2.1 Activating ATP-sensitive Potassium (KATP) Channels

2.2.2 Inhibiting Calcium Channels

2.2.3 Down-regulating Kv4.3 Expression

2.3 Estrogen and Structural Remodeling

Index

   Series:
      Cardiology Research and Clinical Developments
   Binding: Softcover
   Pub. Date: 2009 4th Quarter
   ISBN: 978-1-60692-257-6
   Status: AN
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Estrogen and Myocardial Infarction