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Recollections of Pioneers in Xenotransplantation Research
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Editors: David K. C. Cooper, M.D., Ph.D. (Co-Director, Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, US)
Book Description:
There is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs – i.e., cross-species transplantation, or xenotransplantation – could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of reminiscences by surgeons and scientists who, over the past 50 years, have made major contributions to research into achieving successful transplantation of pig organs and cells into primates. It records the personal work of 22 researchers from North America, Asia, Europe, and Australasia who developed this field, which will have an immense impact on the future medical care of patients with such diverse conditions as heart and kidney failure, diabetes, corneal blindness, and Parkinson’s disease.
A pig organ transplanted into a human or nonhuman primate is rejected within minutes. To overcome this immunological barrier, pigs have been genetically-engineered to protect their tissues from the primate immune response. Today, life-supporting organs from pigs with up to six genetic modifications have functioned for more than a year in nonhuman primates, and the blood sugar of diabetic monkeys has been controlled for more than two years by the transplantation of insulin-producing pancreatic islet cells from pigs. Clinical trials of pig islet and corneal transplantation have already been undertaken, and trials of organ transplants are currently being planned.
The pioneering researchers who contributed to the early development of this field highlight their own roles, and record their personal recollections of the other scientists and surgeons with whom they collaborated. They do not confine themselves to the scientific progress they made, but comment on the roles of industry and academia in moving the field forward.
Recollections of Pioneers in Xenotransplantation Research will be of interest to physicians, scientists, and the lay person with an interest in transplantation or in the care of patients with life-threatening diseases, but also to those interested to understand the potential of genetic-engineering in science and medicine.
The book provides a historical record of the research that has contributed to an advance in medicine that has been called “the next great medical revolution.” Within a few years, this new form of therapy is likely to impact every family in the developed world. (Nova Medicine and Health)

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Table of Contents:

Chapter 1. The “Reemtsma Era”: Recollections of an Acolyte (pp. 1-20)
(Mark A. Hardy)

Chapter 2. Observations on Early Xenograft and Tolerance Experiments and Concepts (pp. 21-26)
(Roy Y. Calne)

Chapter 3. The Next Great Medical Revolution: A Cardiac Surgeon’s Efforts to Develop Xenotransplantation (pp. 27-62)
(David K. C. Cooper)

Chapter 4. Xenotransplantation in Evolution (pp. 63-88)
(Jeffrey L. Platt)

Chapter 5. The Xenotransplantation Effort in Minnesota (pp. 89-108)
(Agustin P. Dalmasso)

Chapter 6. Conquering Complement with Transgenic Pigs 1985-1999: A Reminiscence (pp. 109-122)
(David J. G. White)

Chapter 7. Reminiscences of Xenotransplantation 25 Years Later (pp. 123-140)
(Emanuele Cozzi)

Chapter 8. Antibodies, Gal and CD46: Our Contribution to the Field (pp. 141-158)
(Ian F. C. McKenzie and Mauro S. Sandrin)

Chapter 9. Personal Reflections on the Field of Xenotransplantation (pp. 159-202)
(Richard N. Pierson III)

Chapter 10. Reminiscences of My Involvement in Xenotransplantation (pp. 203-220)
(David H. Sachs)

Chapter 11. Contributions to Development of Xenotransplantation in Oklahoma and Nagoya (pp. 221-240)
(Takaaki Kobayashi)

Chapter 12. Reminiscences of Xenotransplantation Studies (pp. 241-266)
(Shuji Miyagawa)

Chapter 13. Memories and Reflections on Cell Xenotransplantation (pp. 267-274)
(Robert B. Elliott)

Chapter 14. A Journey in Xenotransplantation Science, from Mélies Illumination to Medical Wisdom at the Nantes Institute of Transplantation (pp. 275-288)
(Jean-Paul Soulillou)

Chapter 15. Xenotransplantation: Over 25 Years of Engagement at the Interface between Academia and Industry (pp. 289-310)
(Hendrik Jan Schuurman)

Chapter 16. Organisms Don’t Carry Passports (pp. 311-330)
(Jay Fishman)

Chapter 17. The Dawn of Xenotransplantation Research in Korea (pp. 331-344)
(Curie Ahn)

Chapter 18. Reminiscences about Xenotransplantation (pp. 345-360)
(Chung-Gyu Park)

Chapter 19. Xenotransplantation at and around Ludwig Maximilians University (pp. 361-372)
(Bruno Reichart)

Chapter 20. Clinical Xenotransplantation Trials and Scientific Achievements in Sweden (pp. 373-386)
(Michael E. Breimer)

Chapter 21. The Purposes and Accomplishments of the Secretary’s Advisory Committee on Xenotransplantation (SACX) of the U.S. Department of Health and Human Services, 1999-2005 (pp. 387-400)
(Harold Y. Vanderpool)

Chapter 22. Xenotransplantation: The Official Journal of the International Xenotransplantation Association (pp. 401-408)
(David H. Sachs and David K. C. Cooper)

Chapter 23. The Establishment of the International Xenotransplantation Association: The First Section of The Transplantation Society (pp. 409-418)
(David K. C. Cooper and David H. Sachs)

About the Editor (pp. 419-420)

List of Contributors (pp. 421-424)

Index (pp. 425)

Total Pages: 431

      New Developments in Medical Research
   Binding: Hardcover
   Pub. Date: 2018-August
   ISBN: 978-1-53613-945-7
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Recollections of Pioneers in Xenotransplantation Research