Book Description:
Tumor Necrosis Factor (TNF) is a member of a superfamily of proteins, each with 157 amino acids, which induce necrosis (death) of tumor cells and possess a wide range of proinflammatory actions. Tumor necrosis factor is a multifunctional cytokine with effects on lipid metabolism, coagulation, insulin resistance, and the function of endothelial cells lining blood vessels. Blocking the action of TNF has been shown to be beneficial in reducing the inflammation in inflammatory diseases such as Crohn's disease and rheumatoid arthritis. Inappropriate production of TNF or sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases that include cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Extensive research within the last two decades has shown that TNF can be a potential therapuetic agent in various diseases. This new important book gathers the latest research from around the globe in this field.

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Table of Contents:
Preface

Chapter I. Tumor Necrosis Factor (TNF) ¨C From Bench to Bedside, pp. 1-48
(Indrajit Chowdhury and Ganapathy K Bhat, Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia, USA)

Chapter II. Tumour Necrosis Factor Alpha Neutralization in The Medical Management of Crohn¡¯s Disease, pp. 49-77
(Neil Gerard Docherty, Health Sciences Centre, UCD School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland)

Chapter III. Tumor Necrosis Factor-¦Á and Biliary Tract Diseases, pp. 79-94
(Hiroko Ikeda, Kenichi Harada, Motoko Sasaki, Yasunori Sato and Yasuni Nakanuma,
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan, and others)

Chapter IV. Tumoricidal Effect of Tumor Necrosis Factor-alpha in Isolated Limb Perfusion Treatment of Human Cancers, pp. 95-132
(Chandrakala Menon and Douglas L. Fraker, Harrsion Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia, PA)

Chapter V. Tumor Necrosis Factor Antagonist Induced Psoriatic Skin Lesions, pp. 133-141
(Angelique N. Collamer, MD and Daniel F. Battafarano, DO, Department of Rheumatology, Brooke Army Medical Center, Fort Sam Houston, Texas)

Chapter VI. A New Promising Role of Melatonin in Promoting Tumor Necrosis Factor Toxicity in Cancer Cells, pp. 143-149
(Rosa M. Sainz, Juan C. Mayo, Dun-Xian Tan, Russel J. Reiter, Departamento de Morfolog¨ªa y Biolog¨ªa Celular, Instituto Universitario de Oncolog¨ªa del Principado de Asturias (IUOPA), Universidad de Oviedo, Spain, and others)

Chapter VII. Circulating TNF-¦Á and Oral Health Condition in Elderly Japanese, pp. 153-158
(Hideaki Hayashida, Toshiyuki Saito, Reiko Furugen, Noboru Yamaguchi, Akihiro Yoshihara, Hiroshi Ogawa, and Hideo Miyazaki, Department of Oral Health, Unit of Social Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan , and others)

Chapter VIII. Tumor Necrotic Factor in T-Cell Disorder: Hypothesis and Proof of Idea, pp. 159-163
(Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok Thailand)

Chapter IX. Tumor Necrotic Factor in Malaria, pp. 165-169
(Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok Thailand)

Chapter X. Tumor Necrosis with Special Reference to Autophagic Cell Death; (Self-Cannibalism) and Xeno-Cannibalism in Gastric Cancer, pp. 171-204
(RA Caruso, Dept. of Human Physiology, University of Messina, Italy)

Chapter XI. Tumor Necrosis Factor and Carcinoma by Hepatitis B and C Virus Infection, pp. 205-219
(Kazuya Shirato and Tetsuya Mizutani, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashimurayama, Tokyo 208-0011 Japan)

Index