Book Description:
For many years the mammalian blood cell system has provided cell biologists and hematologists with one of the best experimental models in which to unravel how one stem cell – the hematopoietic stem cell – gives rise to many different types of progeny. Numerous models of lineage relationships have emerged, but the most influential of these, in which differentiating cells undergo a series of binary choices, has been increasingly challenged in recent years – to the extent that the accumulation of new findings recently culminated in a Nature commentary suggesting that “the latest research will necessitate revision of textbook accounts”. This book brings together contributions from many leading experts in the field of blood cell development who each discuss both the overall process of hematopoiesis and the origins and development of each of the cells of the blood and immune systems. It describes how new molecular, cellular and – particularly – transgenic tools are helping us understand the processes that control the lineage fates of hematopoietic stem and progenitor cells and how lineage-committed progeny develop along particular maturation pathways.

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Table of Contents:
From the Editors
Foreword
Abbreviations

Chapter 1. Gene regulatory networks directing cell fates within the hematopoietic system, pp. 1-23
(Damien Reynaud, David W. Lancki, Jagan M. R. Pongubala, Aryeh Warmflash, Aaron R. Dinner and Harinder Singh, The University of Chicago, Chicago, IL USA)

Chapter 2. Lymphoid and myeloid lineage commitment of multipotent hematopoietic progenitors, pp. 25-51
(Motonari Kondo, Thomas F. O’Brien and Anne Y. Lai, Duke University Medical Center, Durham, NC, USA)

Chapter 3. Intracellular signaling for granulocytic and monocytic differentiation, pp. 53-77
(George Studzinski, UMDNJ-New Jersey Medical School, NJ, USA; and Ewa Marcinkowska, University of Wroclaw, Wroclaw, Poland)

Chapter 4. Dendritic cell development, lineage issues and haematopoiesis at the single cell level, pp. 79-120
(Shalin Naik, The Netherlands Cancer Institute, Amsterdam, The Netherlands)

Chapter 5. The making and breaking of a B Lymphocyte, pp. 121-139
(Stephen L Nutt, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia)

Chapter 6. Developmental pathways and molecular regulation of early T cell development in mouse and human, pp. 141-177
(Tom Taghon, Ghent University Hospital, Ghent, Belgium)

Chapter 7. Development of natural killer cell diversity, pp. 179-203
(Christian A.J. Vosshenrich, Nicholas D. Huntington, Vera S.G. Ribeiro, Naoko Satoh-Takayama and James P. Di Santo, Institut Pasteur, Paris, France)

Chapter 8. Thymic epithelial cell development and function, pp. 205-239
(Jason Gill, University of Basel, Switzerland)

Chapter 9. The biology of lymphoid tissue inducer cells, pp. 241-260
(Stephane Chappaz and Daniela Finke, University of Basel, Switzerland)

Chapter 10. A pair-wise relationships model of hematopoietic fate determination, pp. 261-283
(Geoffrey Brown, Robert Michell and Phil Hughes, University of Birmingham, Edgbaston, Birmingham UK; Antonius Rolink, University of Basel, Basel, Switzerland and Rhodri Ceredig, National University of Ireland, Galway, Ireland)

Chapter 11. The epigenetics of haematopoiesis, pp. 285-309
(Karen Brown, Imperial College London, Hammersmith Hospital Campus, London, UK)

Index