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Handbook of Drug Targeting and Monitoring
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Editors: Boris Andreev and Vasily Egorov
Book Description:
Drug monitoring in clinical chemistry refers to the measurement of drug concentration in blood serum/plasma so that an optimal concentration is obtained to benefit patients with minimal toxic adverse effects. Drug delivery systems have been developed for enhancing the pharmacokinetic profile of any given active agent, increasing the accumulation at the target site, while minimizing their systemic distribution. Magnetic colloids, for example, are very promising stimuli-sensitive drug delivery systems because of their magnetic-field responsiveness. This book describes the main synthesis strategies and surface functionalization processes of magnetic colloids, giving an overview of the recent developments in magnetic drug targeting. The possibilities of very promising strategies for controlling the biodistribution profiles of chemotherapy agents are also investigated, including passive and active targeting strategies involving the use of drug carriers. Other chapters in this book examine the application of nanotechnology in pharmacotherapy, therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDS), a mathematical modeling approach to testing drug effects on Hepatitis C virus (HCV), and the recent developments in drug monitoring by high performance liquid chromatography (HPLC).


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Table of Contents:
Preface

Chapter 1. Drug Targeting Strategies in Cancer Treatment, pp. 1-18
(Jos¨¦ L. Arias, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain)

Chapter 2. Drug Targeting by Magnetically Responsive Colloids, pp. 19-111
(Jos¨¦ L. Arias, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain)

Chapter 3. Muscarinic M1 Receptors, Protein Kinase C and Attention: Targets for Treating Alzheimer¡¯s Disease and Schizophrenia, pp. 113-129
(Joshua A. Burk and Andrea M. Robinson, Department of Psychology, College of William and Mary, Williamsburg, VA)

Chapter 4. Molecular Target for Analgesic Effect of Dragon¡¯s Blood ¡ª From Voltage-Gated Sodium Channel to Vanilloid Receptor 1, from Dorsal Root Ganglion to Spinal Dorsal Horn, pp. 131-144
(Chen Su, Xiao Xincai, Liu Xiangming, College of Pharmacy, South-Central University for Nationalities, Wuhan, Hubei, China)

Chapter 5. Hybrid Mesoporous Silica: A Preliminary Attempt to Engineer a Drug Targeting Device, pp. 145-163
(L. Pasquaa, C. Morellib, F. Testaa, D. Siscib, E. Brunellic, J. B.Nagya, R. Aielloa, S. And¨°d, Universit¨¤ degli Studi della Calabria, Rende, Italy, and others)

Chapter 6. Folate-Mediated Targeting of Polymers as Components of Colloidal Drug Delivery Systems, pp. 165-178
(Cavallaro G., Licciardi M., Pitarresi G., Giammona G., Lab. of Biocompatible Polymers, Department of Chimica e Tecnologie Farmaceutiche, University of Palermo, Palermo, Italy)

Chapter 7. Identification of Drug Targets for Hepatitis C Virus using Mathematical Modeling, pp. 179-192
(Elena L. Mishchenko, Kirill D. Bezmaternykh, Vitaly A. Likhoshvai, Vladimir A. Ivanisenko, and Nikola§å A. Kolchanov, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, and others)

Chapter 8. Forecasting Side Effects Resulting from Pharmacologic Intervention with Compounds that Target Lysophosphatidic Acid and Autotoxin, pp. 193-201
(Mandi M. Murph, The University of Georgia College of Pharmacy, Athens, Georgia)

Chapter 9. Induction and Inhibition of the Human Cytochrome P450 3A4 and Implication in Clinical Drug Monitoring, pp. 203-354
(Shu-Feng Zhou, School of Health Sciences, RMIT University, Victoria, Australia)

Chapter 10. Recent Developments in Drug Monitoring by HPLC, pp. 355-423
(Victoria F. Samanidou, Eftichia G. Karageorgou, Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece)

Chapter 11. Warfarin Monitoring: Standard Practice and Beyond, pp. 425-466
(Dr. Gary W. Moore, Dr. Graeme Thomson, Dr. Dominic J. Harrington, Haemostasis Laboratories, GSTS Pathology, Guy¡¯s & St. Thomas¡¯ NHS Foundation Trust, London, UK, and others)

Chapter 12. An Australian Model for a National Medicines Monitoring System, pp. 467-491
(Chris Kelman, The Australian National University, Australia)

Chapter 13. Therapeutic Monitoring of Antiepileptic Drugs, pp. 493-501
(Svein I. Johannessen, Cecilie Johannessen Landmark, Department of Medical Biochemistry, Rikshospitalet University Hospital, Oslo, Norway, and others)

Chapter 14. Balancing Ethical and Legal Compromise during Clozapine Treatment in Developing Countries, pp. 503-508
(Prem Kumar Chandrasekaran, MBBS, NeuroBehavioural Medicine, Penang Adventist Hospital, Malaysia)

Chapter 15. Theranostic: The Near Future of Nanotechnology, pp. 509-512
(José L. Arias, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, Granada, Spain)

Chapter 16. Basic Engineering Processes For Drug Loading To Polymeric Carriers, pp. 513-523
(José L. Arias, Visitación Gallardo, Mª Adolfina Ruiz, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja s/n, Granada, Spain)

Index

   Series:
      Pharmacology - Research, Safety Testing and Regulation
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 7 x 10
   ISBN: 978-1-60741-839-9
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Handbook of Drug Targeting and Monitoring