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Neurochemistry: Molecular Aspects, Cellular Aspects and Clinical Applications
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Editors: Anacleto Paços and Silvio Nogueira
Book Description:
Neurochemistry is the specific study of neurochemicals, which include neurotransmitters and other molecules such as neuro-active drugs that influence neuron function. There is evidence that the neurotransmitter norepinephrine (NE) might be very important in pathophysiology of anxiety and mood disorders. This book analyzes the effect of psychiatric medications on NE system and proposes how the treatment outcome might be improved. Furthermore, Parkinson's disease (PD) is characterized by the degeneration of the dopaminergic nigrostriatal pathway. This book reviews the emerging evidence that points to a future direction of PD etiology research and discusses the oxidative stress of cytosolic dopamine.
Recent research has demonstrated the presence of intrinsic inhibitory mechanisms of axon regeneration in the CNS, and thus presents promising therapeutic strategies for the treatment of patients with CNS injury. This book looks at the molecular mechanisms concerning the inhibition of axon regeneration in the CNS. The role of noradrenaline in interpersonal functioning, and in the adaptive function of human social behaviors is examined as well. Other chapters in this book include a review of the current findings on the relationships between insulin resistance, sympathetic nerve activity and B-adrenoceptor polymorphisms in obesity, hypertension and obesity-related hypertension and a discussion of the diverging roles of dystroglycan and the molecular pathomechanism of neuromuscular diseases caused by defective DG function.

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Table of Contents:

Insulin Receptor Substrate Signaling in the Central Nervous System: From Embryonic Development to Aging;pp. 1-34
(Susanna Freude and Markus Schubert, Department of Internal Medicine II, Center for Molecular Medicine Cologne (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Germany)

Glutamate receptors of the kainate type: an ion channel becoming a metabotropic receptor;pp. 35-55
(José Vicente Negrete-Díaz and Antonio Rodríguez-Moreno, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain)

G protein-coupled receptor heterodimerization : a molecular determinant of neuronal activity;pp. 57-102
(Dominique Massotte, UMR 7104-U964, IGBMC, 1 rue Laurent Fries BP 10142, F-67404 Illkirch cedex, France)

Control of apoptosis in experimental Alzheimer’s disease: therapeutic opportunities for an ancient bile acid;pp. 103-131
(Rita M. Ramalho, Ricardo J. S. Viana, Ana F. Nunes, Walter C. Low, Clifford J. Steer, Cecília M. P. Rodrigues , iMed.UL, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon, Portugal, and others)

The Role of Noradrenaline on Interpersonal Functioning;pp. 133-152
(Wai S. Tse and Alyson J Bond, Department of Applied Social Studies, City University of Hong Kong, Hong Kong, China, and others)

The Roles of Insulin Resistance and Sympathetic Nerve Activity in Obesity and Hypertension - Which Comes First the Blood Pressure or Weight?;pp. 153-173
(Kazuko Masuo, Gavin W. Lambert, and Murray D. Esler, Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia)

Role of Norepinephrine in Affective Disorders;pp. 175-194
(Eliyahu Dremencov, M.Med.Sc., Ph.D., Brains On-Line, BV, and the University of Groningen Institute of Pharmacy, Groningen, Netherlands)

Dystroglycan and Neuromuscular Diseases: Its Diverging Role in Muscle, Nerve and Brain;pp. 195-209
(Fumiaki Saito, Kiichiro Matsumura, Department of Neurology and Neuroscience, Teikyo University School of Medicine, Tokyo, Japan)

Reversible Immortalization for the Expansion of Neural Cells;pp. 211-224
(Filip Lim, Vega Garcia-Escudero and Jesus Avila, Department of Biology, Universidad Autonoma de Madrid, Spain)

Deficiency in Striatal Dopamine Action: An Omen for Parkinson’s Disease?;pp. 225-235
(Lenard Lachenmayer and Zhenyu Yue, Department of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, NY, USA)

Identification of RGS8-interacting Proteins from Mouse Cerebellum;pp. 237-245
(Kiriko Muta, Kazuhide Kii, Keiji Kiyohara, Takahito Watabe, Hisayoshi Tanaka and Osamu Saitoh, Department of Bio-Science, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga, Japan)

Molecular Mechanism Underlying the Inhibition of Axonal Regeneration
after CNS Injury;pp. 247-250
(Rieko Muramatsu, Toshihide Yamashita, Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Japan)

Index pp.251-275

      Neuroscience Research Progress
   Binding: Hardcover
   Pub. Date: 2009
   Pages: pp.275
   ISBN: 978-1-60741-831-3
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Neurochemistry: Molecular Aspects, Cellular Aspects and Clinical Applications