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Poisons: Physiologically Active Substances
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Authors: S.B. Zotov (Volgograd State Technical University, Russia) and O.I Tuzhikov (Volgograd State Technical University, Russia) 
Book Description:
To date, a number of clinically important drugs have been identified that interact with commonly-used herbs and thus herb-drug interactions have become a safety concern in the use of herbal medicines. These drugs include (amongst others) warfarin, midazolam, digoxin, amitriptyline, indinavir, cyclosporine, tacrolimus and irinotecan. Importantly, many of these drugs have very narrow therapeutic indices. Most of them are substrates for cytochrome P450s (CYPs) and/or P-glycoprotein (P-gp). Because drug-herb interactions can significantly affect circulating levels of drug and, hence, alter the clinical outcome, the identification of drugs that interact with commonly-used herbal medicines has important implications in drug development. In silico, in vitro, animal and human studies are often used to identify drug interactions with herbs. This book is of high scientific value because it highlights the relevance of mechanisms, models and maladies.

Table of Contents:
Preface to Second Edition

Chapter 1. Poisons in Mythology, pp. 1-9

Chapter 2. Poisons in the Ancient World, pp. 11-16

Chapter 3. Poisons in the Middle Ages, pp. 17-21

Chapter 4. Development of the Chemistry of Physiologically Active Substances (PhAS) in the Nineteenth and Twentieth Centuries, pp. 23-28

Chapter 5. Poisons and Elementary Bases of Toxicology, pp. 29-37

Chapter 6. Muscarine, pp. 39-59

Chapter 7. Curare, pp. 61-69

Chapter 8. Strongest Nonprotein Poisons, pp. 71-85

Chapter 9. Toxins of Protein and Similar Structures, pp. 87-97

Chapter 10. Chemical Warfare Agents, pp. 99-129

Chapter 11. Harmful Substances in the Environment, pp. 131-145

Chapter 12. Natural and Synthetic PhAS, pp. 147-174

About the Authors and Editor
General Bibliography

      Pharmacology - Research, Safety Testing and Regulation
   Binding: Hardcover
   Pub. Date: 2009
   Pages: 7 x 10, 213 pp.
   ISBN: 978-1-60741-973-0
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Poisons: Physiologically Active Substances