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Narcolepsy: Symptoms, Causes and Diagnosis
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Editors: Guillermo Santos and Lautar Villalba
Book Description:
Narcolepsy is a clinical syndrome defined by four symptoms: a compliant excessive sleepiness, a sudden bilateral loss of postural muscle tone, sleep paralysis and hypnagogic hallucinations. When cataplexy is predominant, narcolepsy can be misdiagnosed as syncope or drop attacks. The authors of this book discuss how to correctly diagnosis narcolepsy and how to avoid certain pitfalls which would lead to erroneous treatments due to the misdiagnosis. Moreover, this book examines the role exerted by obesity in the pathophysiological mechanisms of narcolepsy. This book underlines the importance of body weight as a factor influencing the narcolepsy, indicating also the possible therapeutic strategies by modifications of eating behavior. In addition, modafinil is a mild, wake-promoting stimulant that is pharmacologically distinct from other central nervous system stimulants. This book provides an overview of modafinil's effects on human and animal behavior and in the brain. Other chapters assess narcolepsy in children, the influences of orexin A in the pathophysiological mechanisms of narcolepsy and the prevalence of periodic leg movements (PLM) in people who suffer from narcolepsy.

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Table of Contents:

Autonomic Malfunctions in Mice Model of Narcolepsy, pp.1-34
(Tomoyuki Kuwaki, Wei Zhang, Department of Physiology, Kagoshima, University Graduate School of Medical & Dental Sciences, Kagoshima, Japan, and others)

Modafinil: A Wake-Promoting Stimulant with Multiple Clinical Uses, pp.36-64
(Dennis K. Miller, Marsha M. Dopheide, Department of Psychological Sciences and Bond Life Sciences Center, University of Missouri, Columbia, Missouri, and others)

Lights and Pitfalls in the Diagnosis of Narcolepsy, pp.65-86
(R.S. Calabrò, G. Gervasi, D. Imbesi, P. Bramanti, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy)

Narcolepsy in Children, pp.87-106
(Sona Nevsimalova, Department of Neurology, Charles University, 1st Faculty of Medicine and Teaching Hospital, Prague, Czech Republic)

Narcolepsy: Changes in Memory and Attentional Abilities, pp.107-116
(Sergio Chieffi, Giovanni Messina, Vincenzo De Luca, Marcellino Monda, Department of Experimental Medicine, Section of Physiology, Second University of Naples, Napoli, Italy)

Does Orexin A Control Wakefulness by an Influence on Body Temperature?, pp.117-122
(Marcellino Monda, Giovanni Messina, Andrea Viggiano, Emanuela Viggiano, Vincenzo De Luca, Department of Experimental Medicine, Section of Human Physiology and Clinical Dietetic Service, Second University of Naples, Naples, Italy)

Periodic Leg Movements in Narcolepsy, pp.122-128
(Ahmed Bahammam, Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia)

Body Weight Control and Narcolepsy, pp.129-132
(Marcellino Monda, Messina Giovanni, Sergio Chieffi, Bruno De Luca, Department of Experimental Medicine, Section of Human Physiology and Clinical Dietetic Service, Second University of Naples, Naples, Italy)

Index, pp.133

      Sleep - Physiology, Functions, Dreaming and Disorders
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 6 x 9
   ISBN: 978-1-60876-645-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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