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Mitochondria: Structure, Functions and Dysfunctions
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Editors: Oliver L. Svensson
Book Description:
In cell biology, a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. Mitochondria are often described as "cellular power plants" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of the chemical energy. In addition to supplying cellular energy, mitochondria are involved in a range of other processes, such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth. This book reviews research on the mitochondrial metabolism in age-related neurodegenerative disorders such as Alzheimer's and Parkinson's disease; mitochondria and aging; apoptosis and peritoneal injury; diabetes, mitochondria and brain endothelium dysfunction as a dangerous triad for neurodegeneration.



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Chapter 1 - Mitochondria: The Portrayal of an Executioner (pp. 1-76)
Authors / Editors: (Swapna Chaudhuri, Malabika Bhattacharjee, Department of Laboratory Medicine, School of Tropical Medicine, Kolkata, India, and others)

Chapter 2 - Antiapoptosis and Anti-Antiapoptosis (pp. 77-186)
Authors / Editors: (Valery G.Veresov, Department of Cell Biophysics, Institute of Biophysics and Cell Engineering, Minsk, Belarus)

Chapter 3 - Mitochondrial Metabolism in Age-Related Neurodegenerative Disorders: Alzheimer’s and Parkinson’s Revisited (pp. 187-244)
Authors / Editors: (A.R. Esteves, D.M. Arduino, D.F.F. Silva, D. Martins Branco, C.R. Oliveira, S.M. Cardoso, Centro de Neurociências e Biologia Celular and Faculdade de Medicina, Universidade de Coimbra, Portugal)

Chapter 4 - Mitochondrial Functions in Germ Cell Specification and Cell Fate Decisions (pp.245-246)
Authors / Editors: (Yong-Zhong Zhang, Heide Schatten, Rong-Rong Zhou, Department of Life Sciences, Liaocheng University, Liaocheng, Shandong, China, and others)

Chapter 5 - Mitochondria – In Cellular Life and Death (pp. 247-376)
Authors / Editors: (Indrajit Chowdhury and Ganapathy K Bhat, Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA)

Chapter 6 - Mitochondria and Ageing: Do Mitochondria Play a Key Role? (pp. 377-410)
Authors / Editors: (Eva Babusikova, Milos Jesenak, Comenius University in Bratislava, Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic, and others)

Chapter 7 - Mitochondrial Dysfunctions Related with Oxidative Stress (pp. 411-440)
Authors / Editors: (Alfredo Saavedra-Molina, Istvan Boldogh, Salvador Manzo-Avalos, Christian Cortés-Rojo, Leopoldo Aguilera-Aguirre, Rocío Montoya-Pérez and Attila Bacsi, Instituto de Investigaciones Químico-Biológicas, Facultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez”, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich. México, and others)

Chapter 8 - Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells (pp. 441-470)
Authors / Editors: (Claire Monge, Rita Guzun, Kersti Tepp, Natalja Timohhina, Minna Varikmaa, Peeter Sikk, Tuuli Kaambre, Valdur Saks, INSERM, Laboratorie de Bioenergetique Fondamentale et Appliquee, Universite Joseph Fourier, Grenoble, France, and others)

Chapter 9 - Mitochondria as potential therapeutic targets in mitochondria-related diseases (pp. 471-552)
Authors / Editors: (Amadou K.S. Camara, Mohammed Aldakkak and David F. Stowe, Department of Anesthesiology and Anesthesia Research Medical College of Wisconsin, Milwaukee, WI 53226, and others)

Chapter 10 - Diabetes, Mitochondria and Brain Endothelium Dysfunction: A Dangerous Triad for Neurodegeneration? (pp. 553-578)
Authors / Editors: (Cristina Carvalho, Sónia C. Correia, Renato X. Santos, Susana Cardoso, Maria S. Santos, Paula I. Moreira, University of Coimbra, Coimbra, Portugal, and others)

Chapter 11 - Mitochondrial Dysfunction Induced by Transient Global Brain Ischemia (pp. 579-606)
Authors / Editors: (Peter Racay, Maria Chomova, Zuzana Tatarkova, Peter Kaplan, Dusan Dobrota, Institute of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic)

Chapter 12 - Control of Mitochondrial Outer Membrane Permeability: VDAC Regulation by Dimeric Tubulin and Cytosolic Proteins (pp. 607-634)
Authors / Editors: (Tatiana K. Rostovtseva, Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA)

Chapter 13 - Mitochondrial Regulation of Cellular ROS Metabolism (pp. 635-658)
Authors / Editors: (P. Venditti, L. Di Stefano, S. Di Meo, Dipartimento delle Scienze Biologiche, Sezione di Fisiologia, Università di Napoli, Napoli, Italy)

Chapter 14 - Mitochondrial DNA-Related Respiratory Chain Disorders: From Diagnostic to Treatment Approaches (pp. 659-682)
Authors / Editors: (Michelangelo Mancuso, Daniele Orsucci, Luigi Murri, Gabriele Siciliano, Department of Neuroscience, Neurological Clinic, University of Pisa, Italy)

Chapter 15 - Detection and Function of Mitochondrial and Non-Mitochondrial Heme Proteins in Oxygen Sensing Tissues (pp. 683-708)
Authors / Editors: (Wilhelm Ehleben, Joachim Fandrey, Helmut Acker, Department of Physiology, University Duisburg-Essen, Essen, Germany)

Chapter 17 - Regulation of mitochondrial functions according to the environmental changes in yeast Saccharomyces cerevisiae (pp. 731-768)
Authors / Editors: (Fizikova Anastasia Iu., Sambuk Elena V., Laboratory of Biochemical Genetics, Department of Genetics and Breeding, Biology and Soil Sciences Faculty, Saint-Petersburg State University, 199034, Saint-Petersburg, Universitetskaya emb. 7-9, Russia)

Chapter 18 - Role of Mitochondria in Calcium Homeostasis and Contraction of Smooth Muscle Cells (pp. 769-788)
Authors / Editors: (Etienne Roux, Jean-Pierre Mazat, Marko Marhl, Université de Bordeaux, Laboratory of Respiratory Cell Physiology, Bordeaux, France, and others)

Chapter 19 - Evolution and Coevolution of Tubulin’s Carboxy-Terminal Tails and Mitochondria (pp. 789-810)
Authors / Editors: (Dan L. Sackett, Laboratory of Integrative and Medical Biophysics, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland)

Chapter 20 - Mitochondrial Dysfunctions in Response to Mycotoxins: An Overview (pp. 811-828)
Authors / Editors: (Chayma Bouaziz, Hassen Bacha, Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia)

Chapter 22 - Parkinson-Like Disease by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Toxicity on Energy-linked Non-Synaptic and Intra-Synaptic Mitochondrial Enzyme Systems from Macaca fascicularis Brain (pp. 849-864)
Authors / Editors: (R.F. Villa, A. Gorini, University of Pavia, Department of Forensic Medicine and Pharmacological-Toxicological Sciences, Division of Pharmacological and Toxicological Sciences, Laboratory of Neurochemistry and Molecular Medicine, Pavia, Italy)

Chapter 23 - Inorganic Polyphosphates in Mitochondrial Functions and Dysfunctions (pp. 865-882)
Authors / Editors: (Tatyana V. Kulakovskaya, Lydia P. Lichko, Vladimir M. Vagabov, Igor S. Kulaev, Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow, Russia)
***Open Access Chapter. Free Download Available***

Chapter 25 - The Signalosome Hypothesis for Intracellular Signal Transduction to Mitochondria (pp. 899-912)
Authors / Editors: (Alexandre D. T. Costa, Casey L. Quinlan, Keith D. Garlid, Instituto Carlos Chagas (Fiocruz), Curitiba, PR, Brazil, and others)

Chapter 28 - Spectroscopic Studies of Protomitochondria (pp. 941-954)
Authors / Editors: (N. L. Vekshin, Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow, Russia)

Chapter 29 - The State of Mitochondrial Membrane Ultrastructure as Indicator in the Study of Protective Role of Exogenous Nitrate under Condition of Plant Anaerobic Stress (pp. 955-966)
Authors / Editors: (Boris B. Vartapetian, Lyli I. Polyakova, Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russia)

Chapter 30 - Mitochondria, Apoptosis and Peritoneal Injury (pp. 967-974)
Authors / Editors: (Beatriz Santamaría, Alvaro C. Ucero, Alberto Benito-Martin, Alberto Ortiz, Dialysis Unit, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Instituto Reina Sofía de Investigación Nefrológica, Universidad Autónoma de Madrid, Madrid, Spain)

Chapter 31 - Blue Native PAGE, Basis of the Technique and its Use in Organelle Study: The Mitochondrial Complexome (pp. 975-982)
Authors / Editors: (Alexandre Oliveira Campos, André Martinho de Almeida, Ana Varela Coelho, CIIMAR, Porto, Portugal, and others)

Chapter 32 - Mitochondria are the Main Station in ATP Release via Ins(1,4,5)P3 or Ryanodine- Sensitive Ca2+-Signal Pathway (pp. 983-988)
Authors / Editors: (Takeshi Katsuragi, Medical Research Center, School of Medicine, Fukuoka University, Fukuoka, Japan)

   Series:
      Cell Biology Research Progress
   Binding: Hardcover
   Pub. Date: 2011
   Pages: 1042 pp.
   ISBN: 978-1-61668-346-7
   Status: AV
  
Status Code Description
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FP Final Production
EP Editorial Production
PR At Prepress
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Mitochondria: Structure, Functions and Dysfunctions