Book Description:
In this book, the current understanding of the mechanisms of each beta cell toxins are reviewed, reported toxin resistant insulinoma or immortalized beta cells are summarized, and the different nature of those toxin resistant cells are analyzed. With advancements in cancer stem cell research, the possible involvement of stem cells enrichment after various toxin challenges is also discussed. Moreover, there is a renewed interest in the study of the function of fatty acid synthase (FASN) and fatty-acid synthesis in cancer pathogenesis. This book outlines the role of FASN in cancer development and the preclinical development of FASN inhibitors and their antitumor effects. In addition, Parkinson disease (PD) is a neurodegenerative disorder characterized by a progressive loss of the nigrostriatal dopaminergic neurons. The authors discuss the roles of oxidative modification of the proteins of mitochondrial respiration in the pathogenesis of PD. Furthermore, it has been currently understood that the key role in the physiological and regenerative restoration of adult tissues belongs to adult stems cells. Adult stem cell survival after the action ionizing radiation, hyperthermia and in the conditions of the "ischemia/reperfusion" reaction development are examined.

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Table of Contents:
Preface

Adult Stem Cells Survival after the Action of Ionizing Radiation, Hyperthermia and in the Conditions of the “Ischemia/Reperfusion” Reaction Development (A.G. Konoplyannikov, S. Ya Proskuryakov, M.A. Konoplyannikov, Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk, Russia, and others)pp.1-44

Identification of Specific Mitochondrial Proteins Forming Stable Adducts with 4-Hydroxynonenal within Cardiac Tissue of Type-I Diabetic Animals: Implications for Bioenergetics Dysfunction and Onset of Diabetic Cardiomyopathy (Gregg DiNuoscio, Chao Yuan, Ossama Lashin, Andrea Romani, Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA)pp.45-92

The Bone Marrow Microenvironment in Multilple Myeloma: Cellular and Molecular Basis of Disease Progression (R. Ria, A. Reale, G. Mangialardi, F.Dammacco, D. Ribatti, A. Vacca, Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy, and others)pp.93-124

Respiration and Oxidative Metabolism in Spermatozoa (L. Pintos, M. Córdoba, Instituto de Investigación y Tecnología en Reproducción Animal, Universidad de Buenos Aires, Buenos Aires, Argentina)pp.125-150

Plectin Deficiency and Human Hepatocellular Carcinoma (Yih-Shyong Lai, Yi-Hsiang Liu, Department of Pathology, Hospital and Medical College of Chung Shan Medical University, Taichung, Taiwan, and others)pp.151-172

Studies of Toxic Resistant Beta-Cells: Lessons for the Chemotherapy?
(Liu Hui-Kang, Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC)pp.173-194

Fatty Acid Metabolism in Cancer Cell Survival: A New Anti-Cancer Target (Rut Porta, Ramon Colomer, Teresa Puig, Medical Oncology Deparment, Catalan Institute of Oncology (ICO), Institute of Biomedical Reserch of Girona (IdIBGi)Hospita, Universitari Dr. Josep Trueta, Girona, Spain, and others)pp.195-210

Impaired Mitochondrial Respiration as a Causative Factor in Parkinson's Disease (Haseeb Ahmad Khan, Department of Biochemistry, College of Sciences, King Saud University, Riyadh, Saudi Arabia)pp.211-224

Ecophysiological Look at Organ Respiration in Carnivorous Plants: A Review (Lubomír Adamec, Institute of Botany of the Academy of Sciences of the Czech Republic, Section of Plant Ecology, Tøeboò, Czech Republic)pp.225-236

Index pp.237-263