Book Description:
Insulin resistance (IR) and elevated blood pressure are two key features of the metabolic syndrome, which play an important role in the development of secondary cardiovascular complications. In this book, the effects of insulin resistance on the various vasoactive pathways are explored, which affect the equilibrium between vascular relaxation and constriction. Furthermore, the interaction between estrogen, testosterone and insulin signaling-dependent changes in vascular reactivity and blood pressure are discussed. Also addressed in this book are the mechanisms underlying reciprocal relationships between insulin secretion, insulin resistance and inflammation in the pathological state and in its subsequent improvement. Moreover, the current concepts in understanding the underlying risk factors contributing to insulin resistance are examined, focusing on the role of magnesium deficiency that emerges as potential pathogenic key related with decreasing insulin sensitivity. In addition, it is widely accepted that metabolic syndrome is related to cardiovascular disease and that insulin resistance is one of the causes of metabolic syndrome. The authors discuss thiazolidinediones (TZDs), a class of antidiabetes agents, as a means to improve endothelial dysfunction, prevent atherosclerosis, and significantly reduce the risk of cardiovascular disease.

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Table of Contents:
Preface

Hepatic Insulin Resistance and Nonalcoholic Fatty Liver Disease
(Marcia Barbosa Aguila, Caroline Fernandes-Santos, Alessandra Da Rocha Pinheiro-Mulder, Tatiane Da Silva Faria, Carlos Alberto Mandarim-De-Lacerda, Laboratory of Morphometry, Department of Anatomy and Cell Biology, Institute of Biology, Biomedical Center, State University of Rio de Janeiro, Brazil, and others) pp.1-44

Insulin Resistance: Relationship with Polycystic Ovary Syndrome
(Sharmalar Rajendran, Wai Ping A. Chan, John D. Horowitz, Cardiology Unit, Basil Hetzel Institute, The Queen Elizabeth Hospital, Lyell McEwin Health Services, University of Adelaide, Australia) pp.45-78

Insulin Resistance, Blood Pressure and Sex Hormones
(Harish Vasudevan, Linda Tran and John H. McNeill, Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada)pp.79-104

Insulin Secretion in Insulin Resistance States
(Daniela Miguel Marin, Silvia de Barros-Mazon, Sarah Monte Alegre, Departamento de Clínica Médica, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil)pp.105-128

Role of u-opioid Receptor in the Improvement of Insulin Resistance
(I-Min Liu, Juei-Tang Cheng, Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Yen-Pou, Ping Tung Shien, Taiwan, and others) pp.129-146

Thiazolidinediones to Prevent Cardiovascular Disease
(Kazuaki Nishio, Heights Matsugaoka 202, Yamanashi, Japan)pp.147-166

The Role of Magnesium in the Pathogenesis of Insulin Resistance
(Fernando Guerrero-Romero, Martha Rodríguez-Morán, Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico)pp.167-182

Association of Insulin Resistance in Women with Polycystic Ovarian Syndrome, its Familial Transmission and Effect of Rising Body Mass Index (Fauzia Haq Nawaz, Tahira Naru, Javed Haider Rizvi, Aga Khan University Hospital, Karachi, Pakistan, and others)pp.183-194

The Discovery and Meaning of “Partial or Non-Classical Insulin-Resistance”: The Wide Spectrum of Insulin Sensitivity
(M.E. Street, A. Smerieri, M. Petraroli, I. Viani, S. Bernasconi, Department of Pediatrics, University Hospital of Parma, Italy)pp.195-204

The Etiology of Obesity-Induced Insulin Resistance
(Kyle L. Hoehn, William L. Holland, Trina A. Knotts, Scott A. Summers, Diabetes and Obesity Program, The Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia, and others)* pp.205-238

Index pp.239-259