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Meconium Aspiration Syndrome: From Pathomechanisms to Treatment
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Authors: Daniela Mokra and Juraj Mokry (Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia, European Union) 
Book Description:
Meconium aspiration syndrome (MAS) is a major cause of respiratory morbidity and mortality in the term and post-term newborns. Aspirated meconium obstructs the airways and subsequently may cause an alveolar atelectasis behind the plug, air-trapping, and air leak. In a very short time after the aspiration, meconium triggers a progressive dysfunction of pulmonary surfactant, chemical pneumonia, and ventilation/perfusion mismatch, which often leads to persistent pulmonary hypertension. Due to complex pathophysiology and multiple interactions between the individual pathomechanisms, MAS is often difficult to treat. Therapeutic protocols usually include airway suctioning, ventilator support or artificial ventilation, in severe cases also administration of exogenous surfactant, inhaled NO, partial liquid ventilation, or anti-inflammatory treatment. Growing information on the role of various pathomechanisms participating in the meconium-induced respiratory, inflammatory, and cardiovascular changes widens the spectrum of drugs which may be perspectively beneficial in the treatment of MAS.

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Table of Contents:
Preface

Chapter I. Introduction, pp.1-2

Chapter II. Meconium Aspiration Syndrome (MAS), pp. 3-4

Chapter III. Passage of Meconium, pp. 5-6

Chapter IV. Aspiration of Meconium , pp. 7-8

Chapter V. Pathomechanisms of MAS, pp. 9-32

Chapter VI. Clinical Features, pp. 33-34

Chapter VII. Radiographic Features, pp. 35-36

Chapter VIII. Long-Term Sequelae, pp. 37-38

Chapter IX. Animal Models, pp. 39-40

Chapter X. Prevention and Treatment of MAS, pp. 41-76

Chapter XI. Concluding Remarks, pp. 77-78

References

Index

   Series:
      Pregnancy and Infants: Medical, Psychological and Social Issues
   Binding: Softcover
   Pub. Date: 2010
   Pages: 6 x 9
   ISBN: 978-1-60876-944-5
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Meconium Aspiration Syndrome: From Pathomechanisms to Treatment