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Insulin Receptor Substrate Signaling in the Central Nervous System
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Authors: Susanna Freude and Markus Schubert (University of Cologne, Germany) 
Book Description:
Recent advance in molecular biology revealed new insights into the function of insulin receptor signaling and insulin receptor substrate (IRS) protein mediated signals in the central nervous system (CNS) in vivo. The IRS proteins mediate mainly intracellular effects of the insulin-like growth factor-1 receptor (IGF-1R) and the insulin receptor (IR). The functions of IRS proteins in peripheral tissues like muscle, liver, pancreas and fat have been characterized in detail. This book examines why IRS signaling is not only critical during brain development, but also for reproduction, energy homeostasis, aging and possibly for neurodegenerative diseases in humans.

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Table of Contents:
Introduction pp.1-2

IRS and IRS-like protein signal transduction pp.3-6

IRS and IRS-like protein receptors pp.7-10

Peripheral functions of IRS and IRS-like proteins pp.11-14

IRS signaling system in the CNS pp.15-16

IRS signaling in pre-and postnatal brain development pp.17-18

IRS signaling in CNS disease pp.19-24

IRS signaling in metabolism and energy homeostasis pp.25-28

IRS signaling and fertility pp.29-30

IRS signaling in aging pp.31-34

Conclusion pp.35-36

Index pp.58-67

   Series:
      Protein Science and Engineering
   Binding: Softcover
   Pub. Date: 2010
   Pages: pp.67
   ISBN: 978-1-61668-255-2
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Insulin Receptor Substrate Signaling in the Central Nervous System