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TRP Channels in Health and Disease: Implications for Diagnosis and Therapy
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Editors: Arpad Szallasi (Monmouth Medical Center, Long Branch, NJ, USA)
Book Description:
Changes in temperature, either hot or cold, is sensed through direct activation of members of the temperature-sensitive transient release potential (TRP) ion channel superfamily, the so-called “thermoTRPs”. Of the 28 TRP channels discovered today, seven sense hot or warm temperatures whereas two are activated by cold. Together, these channels cover a wide temperature range with extremes that fall between 10 C and 53 C. This new and unique book reviews research on TRP channels and their relation to health and disease.

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Chapter 1 - TRP Channels in Health and Disease: An Overview pp. 1-15
Authors / Editors: (Gina Story, Pain Center, Washington University School of Medicine, St. Louis, MO, USA)

Chapter 2 - TRP Channelopathies pp. 17-38
Authors / Editors: (Bernd Nilius and Grzegorz Owsianik, Department of Molecular Cellular Biology, Catholic University, Leuven, Belgium)

Chapter 3 - TRP Polymorphism pp. 39-50
Authors / Editors: (Hyungsuk Kim, Michael J. Iadarola and Ray A. Dionne, National Institute of Nursing Research and National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA)

Chapter 4 - Complex Regulation of TRP Channels by PIP2 pp. 51-71
Authors / Editors: (Tibor Rohacs, Department of Pharmacology, UMDNJ – New Jersey Medical School, Newark, NJ, USA)

Chapter 5 - TRP Channel Trafficking pp. 73-86
Authors / Editors: (Rosa Planells-Cases, María Camprubí-Robles and Antonio Ferrer-Montiel, Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain)

Chapter 6 - Disease-Related Changes in TRP Channel Expression: Clinical Studies pp. 87-102
Authors / Editors: (Ravikiran Shenoy, Katherine Roberts and Praveen Anand, Department of Clinical Neuroscience, Imperial College, London, UK)

Chapter 7 - Targeting Supraspinal TRP Channels for Pain Relief pp. 103-120
Authors / Editors: (Enza Palazzo, Vito de Novellis, Francesca Rossi and Sabatino Maione, Department of Experimental Medicine, University of Naples, Italy)

Chapter 8 - Role of Transient Receptor Potential Channels in Thermosensation and Thermoregulation pp. 121-152
Authors / Editors: (Marcello Trevisani and Arpad Szallasi, Pharmeste, Ferrara, Italy and Department of Pathology, Monmouth Medical Center, Long Branch, NJ, USA)

Chapter 9 - TRP Channels and Osmoregulation pp. 153-170
Authors / Editors: (Wolfgang Liedtke, Center for Translational Neuroscience, Duke University School of Medicine, Durham, NC, USA)

Chapter 10 - TRP Channels and Blood Pressure Regulation pp. 171-196
Authors / Editors: (Ryuji Inoue and Juan Shi, Department of Physiology, Fukuoka University School of Medicine, Fukuoka, Japan and Department of Anatomy and K.K. Leung Brain Research Centre, the Fourth Military Medical University, China)
***Open Access Chapter. Free Download Available***

Chapter 11 - TRP Channels in Feeding and Body Weight pp. 197-208
Authors / Editors: (Arianne L. Motter and Gerard Ahern, Department of Pharmacology, Georgetown University, Washington DC, USA)

Chapter 12 - TRP Channels and Cancer pp. 209-222
Authors / Editors: (Dimitra Gkika and Natalia Prevarskaya, INSERM U800, Laboratorie de Physiologie Cellulaire, USTL, Université de Lille, France)

Chapter 13 - Transient Receptor Potential Channels in Kidney pp. 223-241
Authors / Editors: (Paolo Mené, Giorgio Punzo and Nicola Pirozzi, Department of Clinical Sciences, “Sapienza” University of Rome, 2nd Medical School, Division of Nephrology. Sant’Andrea University Hospital, Rome, Italy)

Chapter 14 - TRP Channels in the Prostate and Urinary Bladder and Prostate: Implications for Therapy pp. 243-258
Authors / Editors: (Ana Charrua and Francisco Cruz, Institute of Histology and Embryology, Faculty of Medicine of Porto, Porto, Portugal; Instituto de Biologia Molecular e Cellular, Universidade do Porto, Porto, Portugal; and Department of Urology, Hospital São João and Faculty of Medicine, Porto, Portugal)

Chapter 15 - TRP Channels in the Gastrointestinal Tract pp. 259-290
Authors / Editors: (Peter Holzer, Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria)
***Open Access Chapter. Free Download Available***

Chapter 16 - TRP Channels and Airway Diseases pp. 291-315
Authors / Editors: (Riccardo Patacchini and Maurizio Civelli, Preclinical R&D Department, Chiesi Farmaceutici, Parma, Italy)

Chapter 17 - TRP Channels and Migraine pp. 317-329
Authors / Editors: (Francesco De Cesaris, Silvia Benemei, Paola Nicoletti, Jay G. Capone and Pierangelo Geppetti, Headache Center, University Hospital Careggi, and Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy and others)

Chapter 18 - TRP Channels in Cutaneous Biology in Health and Disease pp. 331-361
Authors / Editors: (Tamás Bíró and Ralf Paus, Department of Physiology, University of Debrecen, Research Center for Molecular Medicine, Debrecen, Hungary and Department of Dermatology, University Hospital Schleswig-Holstein, Lübeck, Germany)

Chapter 19 - TRP Channels in Neurodegenerative Disease and Stroke pp. 363-392
Authors / Editors: (Matthew McNeill and Robert A. Cornell, Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA and Department of Anatomy and Cell Biology, carver College of Medicine, University of Iowa, Iowa City, IA, USA)
***Open Access Chapter. Free Download Available***

Chapter 20 - TRP Channels in Brain: Psychiatric Disorders pp. 393-413
Authors / Editors: (Loris A. Chahl, Centre for Brain and Mental Health Research, University of Newcastle, and Schizophrenia Research Institute, NSW, Australia)

Chapter 21 - Role of TRP Channels in Drug Dependence pp. 415-424
Authors / Editors: (Manish Rautham and X.Z. Shawn Xu, Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA)

Chapter 22 - TRP Channels and Sepsis pp. 425-440
Authors / Editors: (Elizabeth S. Fernandes, Gabor Pozsgai and Susan D. Brain, Cardiovascular Division, Department of Pharmacology, King’s College, London, UK)

Chapter 23 - Targeting TRP Channels: An Overview of Current Drug Discovery efforts and future directions pp. 441-472
Authors / Editors: (Samer R. Eid, Eric D. Crown and Mark O. Urban, Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, Philadelphia, PA, USA)

Chapter 24 - TRPV1 Agonists in Clinical Trials for Pain pp. 473-490
Authors / Editors: (Christopher Noto and Marco Pappagallo, Department of Anesthesiology, Division of Pain Medicine, Mount Sinai School of Medicine, New York, USA)

Chapter 25 - TRPV1 antagonists in Clinical Trials pp. 491-514
Authors / Editors: (Martin J. Gunthorpe and Boris A. Chizh, Neurociences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, UK; Clinical Pharmacology, GlaxoSmithKline, Addenbrooke’s Centre for Clinical Investigation, Cambridge, UK)

Chapter 26 - Concluding Remarks and Future Directions pp. 515-533
Authors / Editors: (Shaya Lev and Baruch Minke, Department of Physiology and the Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem, Israel)

      Medicine and Biology Research Developments (Series Editor - Tsisana Shartava, M.D. - Tbilisi, Georgia)
   Binding: Hardcover
   Pub. Date: 2011 3rd Quarter
   Pages: 7 x 10
   ISBN: 978-1-61668-337-5
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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TRP Channels in Health and Disease: Implications for Diagnosis and Therapy