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Insulin Resistance and Nonalcoholic Fatty Liver Disease (NAFLD) / Nonalcoholic Steatohepatitis (NASH)
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Authors: Masato Yoneda, Yuichi Nozaki, Koji Fujita, Atsushi Nakajima (Yokohama City University, Yokohama, Japan) 
Book Description:
The liver is the first organ to receive nutrients that enter the body via the intestines after a meal, and this organ plays a pivotal role in energy metabolism. Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the world and is now considered to be a component of metabolic syndrome. A wide spectrum of histological changes has been observed in NAFLD, ranging from simple steatosis, which is generally non-progressive, to nonalcoholic steatohepatitis (NASH), liver cirrhosis, liver failure, and sometimes even hepatocellular carcinoma. This book reviews recent evidence concerning insulin resistance and NAFLD/NASH as a step towards a comprehensive understanding of the pathophysiology and treatment of NAFLD/NASH.


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Table of Contents:
Introduction pp.1-4

NAFLD and Insulin Resistance (IR)pp.5-6

Pathophysiology of NASH: Insulin Resistance, Free Fatty Acids and Cytokines pp.7-8

Adiponectin and NASH pp.9-10

TNF- and NAFLD/NASH pp.11-12

Leptin and NAFLD/NASH pp.13-14

Peroxisome Proliferators-Activated Receptors (PPARs) and NAFLD/NASH pp.15-16

Iron Overload and NAFLD/NASH pp.17-18

Mitochondrial Abnormalities and NAFLD/NASH pp.19-20

Genetic Influences in NAFLD / NASH pp.21-24

Therapeutic Strategy for NASH Patients pp.25-28

Natural History of NAFLD pp.29-32

References pp.33-50

Index pp.51-54

   Series:
      Metabolic Diseases - Laboratory and Clinical Research
   Binding: Softcover
   Pub. Date: 2010
   Pages: 54.pp
   ISBN: 978-1-61668-927-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Insulin Resistance and Nonalcoholic Fatty Liver Disease (NAFLD) / Nonalcoholic Steatohepatitis (NASH)