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Polyamine-Containing DNA Fragments
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Authors: V. F. Zarytova and A. S. Levina (Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation) 
Book Description:
Polyamines are known to play an essential role in living organisms, where they act as metabolic regulators, in cell proliferation and differentiation, and as stabilizing agents of nucleic acid structure and conformation. Polyamines are also known to protect DNA from damage caused by external agents, such as reactive oxygen species or radiation. The essential role of polyamines for maintaining cell growth has been widely documented. Polyamines can stabilize double- and triplex-stranded DNAs. Furthermore, polyamines and their derivatives can be used as condensing agents to package genes of interest for efficient transfection into living cells. This new book discusses aspects concerning polyamines and nucleic acid fragments including the synthesis of covalent polyamine-oligonucleotide conjugates, the preparation of DNA arrays using polyamines, and the use of polyamines as vehicles to deliver nucleic acids into cells.



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Table of Contents:
INTRODUCTION

1. SYNTHESIS OF POLYAMINE-OLIGONUCLEOTIDE CONJUGATES, pp. 5-30

2. POLYAMINES FOR PREPARING DNA CHIPS, pp. 31-48

3. TRANSFER OF NUCLEIC ACIDS INTO LIVING CELLS WITH POLYAMINES, pp. 49-59

CONCLUSION

INDEX

   Series:
      Cell Biology Research Progress
      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
   Binding: Softcover
   Pub. Date: 2011
   Pages: 6 x 9, 84pp.
   ISBN: 978-1-61728-346-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Polyamine-Containing DNA Fragments