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Decreasing Oxidative Stress and Retarding the Aging Process
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Authors: Borut Poljsak (University of Ljubljana, Slovenia) 
Book Description:
Aging is an inevitable biological process that affects most living organisms. The link between metabolic rate and reactive oxygen species production is an important and long-standing question, and a source of much controversy. A by-product of cell respiration in mitochondria is the formation of reactive oxygen species due to electron leakage from the electron transport chain during oxidative phosphorylation. In simple terms, humans are aging due to oxygen consumption. Damage induced by oxygen appears to be the major contributor to aging and the degenerative diseases of aging such as cancer, cardiovascular disease, immune system decline, and brain dysfunction. This book presents the reasons for oxidative stress formation and the answer to why during the course of evolution the process of free radical damage and defense did not become more perfect so as to produce less free radicals.

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Table of Contents:
1. Introduction to the Aging Process; pp. 1-5

1.2 Aging Theories; pp. 6-15

2. Description of the Problem; pp. 1

2.1 Reactive Oxygen Species and the Oxidative Stress; pp. 17-29

2.1.1 Major Forms of ROS in Biological Systems; pp. 30-33

2.1.2 ROS as a Cause of the Oxidative Damage; pp. 33-35

2.2 Defenses Against ROS; pp. 35

2.2.1 Primary Endogenous Antioxidant Defenses; pp. 35-38

2.2.2 Secondary Antioxidant Defenses; pp. 38-41

3. Metabolic Rate and Life Span; pp. 43-47

4. The Evolutionary Reasons for Not Perfecting the Prevention of Free Radical Formation; pp. 49

4.1 Reactive Oxygen Species and Famine; pp. 49-52

4.2 Reactive Oxygen Species and Infections; pp. 51-52

4.3 Reactive Oxygen Species in Cell Signalling; pp. 52-53

4.4 Reactive Oxygen Species and Evolution; pp. 53-57

5. Methods to Decrease Oxidative Stress and Retard the Aging Process; pp. 59-60

5.1. Mitochondrial Uncoupling; pp. 60-64

5.1.1 Uncoupling and Heat Production; pp. 64-68

5.2. The Roles of Macro and Micronutrients; pp. 68

5.2.1 Metal Ions That Can Increase ROS in Cells; pp. 68-72

5.3. The Induction of Adaptive Responses to Stress Conditions: The Role of the Hormesis Effect as an Example of a Beneficial Type of Stress; pp. 72-77

5.3.1 Caloric Restriction and Reactive Oxygen Species; pp. 78-86

5.3.2 Exercise and Reactive Oxygen Species; pp. 86-90

5.4 Food and ROS Formation; pp. 91

5.4.1 Foods that Increase Reactive Oxygen Species Formation; pp. 91-94

5.4.2 Foods that Decrease Oxidative Stress; pp. 94-102

5.4.3 Foods that Decrease Chronic Inflammation; pp. 102-111

5.4.4 The Importance of Eating Habits; pp. 111-112

5.5 The Importance of Lifestyle; pp. 113

5.5.1 Sleeping and Melatonine Production; pp. 113

5.5.2 Avoidance of Polluted Environments; pp. 114-115

5.5.3 Avoid Excessive Psycho-Physical Stressful Situations; pp. 115-117

5.6 Can Antioxidants as Dietary Supplements Offer Appropriate Protection against ROS-Induced Damage?; pp. 118-119

5.6.1 Antioxidants and Clinical Trials; pp. 119-130

6. How Do Methods Claiming to Decrease Oxidative Stress Compare with Studies on Long-Lived Populations?; pp. 131-133

6.1 Intrinsic Factors (Genes) vs. Extrinsic Factors (Life-Style and Environment) - What’s the Centenarians’ Secret?; pp. 133-136

7. Methodology for Detection of Oxidative State in Biological Systems; pp. 137-142

8. Conclusion; pp. 143-158

9. Key References; pp. 159-193


      Aging Issues, Health and Financial Alternatives
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 6 x 9
   ISBN: 978-1-61728-345-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Decreasing Oxidative Stress and Retarding the Aging Process