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Recollections of 45 Years in Research: From Protein Chemistry to Polymeric Drugs to the EPR Effect in Cancer Therapy
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Authors: Hiroshi Maeda (Sojo University, Kumamoto, Japan) 
Book Description:
This book describes the lifelong research experience of a scientist, from the beginning studies of protein chemistry to the development of a protein drug. Also discussed herein include the invention of the first polymer conjugate drug¡ªpoly(styrene-co-maleic acid (SMA) conjugated to NCS, £­called SMANCS. The author, having acquired knowledge of proteases and inhibitors, pioneered investigations of microbial proteases in the pathogenesis of bacterial infection. The author¡¯s group, using a polymer-conjugated enzyme, discovered an enormous burst in the generation of superoxide anion radical during influenza virus infection by the generation of xanthine oxidase, which was found to be the major cause of the pathogenesis of this viral infection, which progressed even after the virus was eradiated. (Imprint: Nova Biomedical)

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Table of Contents:
Preface

Introduction

1. Bon Voyage: Passage to the Macromolecular World and Protein Chemistry, pp.3-4

2. Back to Sendai and the World of Antibiotics, pp.5-6

3. On to the United States: Work at Children's Research Foundation and Harvard Medical School, pp.7-8

4. Kumamoto University in Kyushu, Japan, pp.9-12

5. SMANCS in Clinics and Beyond: The Discovery of the EPR Effect, pp.13-14

6. The Power of Intra-Arterial Injection of the Polymeric Drug SMANCS/LIPIODOL, pp.15-18

7. Back to the Basics in Infection, Inflammation, and Cancer: The Roles of Proteases, Reactive Oxygen Species (ROS), and Reactive Nitrogen Species (RNS) in Pathogenesis, pp.19-28

8. Clarifying Details of the EPR Effect: A Universal Solid Tumor-Targeting Principle of Macromolecular Anticancer Agents, pp.29-34

9. Factors Facilitating the EPR Effect, pp.35-38

10. Further Enhancement of the EPR Effect, pp.39-46

11. SMA as a Versatile Micelle-Forming Agent, pp.47-50

12. Protein Drugs, Then and Now, pp.51-54

13. Organizing Various Academic Meeting, pp.55-56

Acknowledgments, pp.57-58

About the Author, pp.59

References, pp.61

Index, pp.73

   Series:
      Protein Biochemistry, Synthesis, Structure and Cellular Functions
   Binding: Softcover
   Pub. Date: 2012 1st quarter
   Pages: 5.5 x 8.5 (NBC - C)
   ISBN: 978-1-61761-101-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Recollections of 45 Years in Research: From Protein Chemistry to Polymeric Drugs to the EPR Effect in Cancer Therapy