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Biophysics of DNA-Antibiotic Complexes
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Authors: Nikolai Vekshin (Russian Academy of Sciences, Moscow, Russia) 
Book Description:
This book presents the basic results on studies of the interaction of anti-cancer Actinomycin antibiotics with DNA. It focuses on interactions of heterocyclic anti-tumor antibiotics (Actinomycins, as typical example) with DNA, poly-nucleotides, oligonucleotides, and aggregates of purines, using spectroscopic methods. Experimental data, various models of structures of the complexes and their physical and chemical properties are described, and possible approaches for delivery of heterocyclic antibiotics to DNA are also discussed.
(Imprint: Nova Biomedical)

Table of Contents:

Chapter 1. Introduction, pp. 1-12

Chapter 2. Formation of complexes with DNA, pp. 13-28

Chapter 3. Spectral properties of Actinomycins, pp. 29-59

Chapter 4. Cluster sites in DNA, pp. 61-71

Chapter 5. Single-chain structures and Actinomycins, pp. 73-84

Chapter 6. Spectroscopic analysis of DNA in films, pp. 85-97

Chapter 7. Fluorescence correlation spectroscopy of 7AAMD, pp. 99-109

Chapter 8. The problem of delivery of antibiotics to the cellular DNA, pp. 111-121

Chapter 9. Action of Actinomycin and caffeine on Saccharomyces, pp. 123-138

Chapter 10. Displacement of 7AAMD in HP1 by Hoechst, pp. 139-144

Conclusion, pp. 145-162


      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
   Binding: Hardcover
   Pub. Date: 2011 - 2nd Quarter
   Pages: 6 x 9 (NBC - C)
   ISBN: 978-1-61761-199-5
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Biophysics of DNA-Antibiotic Complexes