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CACO-2 Cells and their Uses
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Editors: Megan A. Schulz
Book Description:
CACO-2 cell cultures are widely used in vitro models in several scientific fields such as nutrition, physiopathology, pharmacology, and toxicology. When cultured onto filters, these cells form a highly polarized epithelium that allows discrimination between apical and basolateral compartments. This new book presents topical research in the study of CACO-2 cells and their uses. Topics discussed include the application of CACO-2 cell models as a supportive in vitro tool during drug discovery and formulation; co-culture systems with CACO-2 cells to evaluate the bioactivity of plant extracts and the use of CACO-2 cells in intestinal transport, cell-matrix interactions and wound healing in intestinal villus cells. (Imprint: Nova Press)

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Please click on a chapter below to purchase separately

Chapter 1 - The Industrial and Academic Rationale of Caco-2 Cell Models Today pp. 1-30
Authors / Editors: (Katja Berginc, Alenka Zvonar, Mirjana Gašperlin, Albin Kristl, The Department for Biopharmacy and Pharmacokinetics, Faculty of Pharmacy, University of Ljubljana, Aškerčeva, Ljubljana, Slovenia, and others)

Chapter 2 - A Critical Perspective on Cell Lines Studies in Nutrition: The Case of Intestinal Absorption pp. 31-48
Authors / Editors: (C. Frontela-Saseta, P. Peso-Echarri, C. González-Bermúdez, R. López-Nicolás, C. Martínez-Graciá, G. Ros-Berruezo, National Research Institute for Food and Nutrition (INRAN), Rome, Italy, and others)

Chapter 3 - Co-Culture Systems with CACO-2 Cells to Evaluate the Bioactivity of Plant Extracts Co-Culture Systems with CACO-2 Cells to Evaluate the Bioactivity of Plant Extracts pp. 49-60
Authors / Editors: (Montserrat Pinent, M. Teresa Blay, Anna Ardévol, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain)

Chapter 4 - The Use of CACO-2 Cells in the Study of Intestinal Transport pp. 61-75
Authors / Editors: (Raquel Martín-Venegas, Ruth Ferrer, Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain)

Chapter 5 - Caco-2 Cells as an Experimental Model for the Study of Cell-Matrix Interactions and Wound Healing in Intestinal Villus Cells pp. 77-88
Authors / Editors: (Amira Seltana, Nuria Basora, Jean-François Beaulieu, CIHR Team on the Digestive Epithelium, Département d’Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, QC, Canada)
***Open Access Chapter. Free Download Available***

Chapter 6 - Effect of Polyunsaturated Fatty Acids and Bile Salts on Butyrate Uptake by Intestinal Epithelial Cells pp. 89-99
Authors / Editors: (Pedro Gonçalves, João R. Araújo, Fátima Martel, Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Porto, Portugal)

Chapter 7 - Analysis of Botulinum Toxin: Intestinal Epithelial Barrier Interaction using Epithelial Monolayer Culture Systems pp. 101-111
Authors / Editors: (Yukako Fujinaga, Takuhiro Matsumura, Yo Sugawara, Laboratory for Infection Cell Biology, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Yamada-oka, Suita, Osaka, Japan)

Chapter 8 - Caco 2 Cells and Genotoxicity Studies of Food Contaminants Caco 2 Cells and Genotoxicity Studies of Food Contaminants pp. 113-128
Authors / Editors: (V. Fessard, L. Le Hégarat, Anses, French Agency for Food, Environment and Occupational Health Safety, Unit of Toxicology of Contaminants, La Haute Marche, Fougères, France)

Chapter 9 - CACO-2 Cells for Studying Intestinal Absorption Mechanisms: Comparison and Correlations with Rat Model pp. 129-163
Authors / Editors: (Victor Mangas-Sanjuan, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Marival Bermejo Sanz, Universidad Miguel Hernández, Spain)

Chapter 10 - Nanocarrier Absorption Studies with CACO-2 Cells pp. 165-180
Authors / Editors: (Frederic Lagarce, Emilie Roger, Inserm U646 Angers)

Chapter 11 - Caco-2 Cells as a Model to Study the Intestinal Effects of Non-Absorbable Phytochemicals pp. 181-196
Authors / Editors: (A.G. Erlejman, C.G. Fraga, P.I. Oteiza, Departament of Biological Chemistry, School of Exacts and Natural Sciences,University of Buenos Aires-CONICET, Buenos Aires, Argentina, and others)

      Cell Biology Research Progress
   Binding: Hardcover
   Pub. Date: 2011 3rd quarter
   Pages: 6 x 9 (NBC - R)205pp.
   ISBN: 978-1-61209-917-0
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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CACO-2 Cells and their Uses