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Serpins and Protein Kinase Inhibitors: Novel Functions, Structural Features and Molecular Mechanisms $265.00
Editors: Bojidor Georgiev and Sava Markovski
Book Description:
Serpins, a group of proteins with similar structures, were first identified as a set of proteins able to inhibit proteases. The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation and inflammation. Today, over 1000 serpins have been identified, including 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors. In contrast, a protein kinase inhibitor is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Protein tyrosine kinases (PTKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration and survival. Due to their involvement in various forms of cancer, PTKs have become prominent targets for therapy. This new book gathers the latest research from around the globe in this dynamic field.

Table of Contents:
Preface

Serpin-Related Diseases (Aleksandra Topic—Institute of Medical Biochemistry, Faculty of Pharmacy, Belgrade, Serbia) pp.1-36

The Roles of Mammalian Mitogen-Activated Protein Kinase-Activating Protein Kinases (MAPKAPKs) in Cell Cycle Control
(Sergiy Kostenko, Alexey Shiryaev, Nancy Gerits, Ugo Moens - Univ. of Tromso, Faculty of Medicine, Institute of Medical Biology, Dept. of Microbiology and Virology, Tromso, Norway)pp.27-62

Rho-Kinase Inhibitor in Kidney Disease
(Toshio Nishikimi - Dept. of Hypertension and Cardiorenal Medicine, Dokkyo Medical Univ., Mibu, Japan pp.63-88

Targeting the Epidermal Growth Factor Receptor Pathway in Glioblastoma Multiforme and Other Intracranial Malignancies
(Marc-Eric Halatsch, Georg Karpel-Massler - Dept of Neurosurgery, Univ. of Heidelberg, Heidelberg, Germany)pp.89-106

The Serine Proteinase Inhibitor Z Alpha-1 Antitrypsin: Acting on the NF-kappaB System for Cytotoxicity (Matthew William Lawless, Department of Clinical Medicine, Trinity College, Dublin, St. James Hospital, Ireland)pp.107-124

Src Family Kinase Inhibitors in Cancer Therapy
(Faye M. Johnson, Gary E. Gallick - Dept. of Thoracic/Head and Neck Medical Oncology, The Univ. of Texas, Houston, TX, and others)pp.125-152

Protein Kinase Inhibitors in Cancer
(Yiguo Hu, Shaoguang Li - The Jackson Laboratory, Bar Harbor Maine)pp.153-166

Protein Kinase Inhibitors: New Research
Panagiotis Samaras, Frank Stenner - Department of Oncology, Univ. Hospital Zurich, Raemistrasse, Switzerland)pp.167-182

PAI-1 and the Diet-Induced Obesity Phenotype: Background Effects and Inbreeding (Bart M. De Taeye, Tatiana Novitskaya, and Douglas E. Vaughan, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN)pp.183-198

The Structure of á1-Proteinase Inhibitor Polymer: Facts and Hypothesis
(Ewa Marszal—Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland)pp.199-210

SERPINA5 Expression in the Male Reproductive Tract is altered with Advanced Age
(Matthew D Anway—Center For Reproductive Biology, Department of Biological Sciences, University of Idaho, Moscow, ID)pp.211-218

Vaspin: Visceral Adipose Tissue-Derived Serpin with Insulin-Sensitizing Effects (Jun Wada —Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan)pp.219-228

Effect of Alpha2-antiplasmin on Tissue Remodeling
Yosuke Kanno and Hiroyuki Matsuno—Dept. of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, Doshisha Women’s Collage of Liberal Arts, Kyoto, Japan)pp.229-236

Index pp.237-257

   Series:
      Protein Biochemistry, Synthesis, Structure and Cellular Functions
   Binding: ebook
   Pub. Date: 2009 4th Quarter
   Pages: pp.257
   ISBN: 978-1-61209-350-5
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Serpins and Protein Kinase Inhibitors: Novel Functions, Structural Features and Molecular Mechanisms