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Techniques in Epidermal Biology: An Integrated Approach to Autoimmune Skin Disease
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Authors: Nicola Cirillo (University of Bristol, Bristol, UK) 
Book Description:
The high-throughput techniques underlying a systems level analysis of biological organisms have emerged as powerful tools in the study of disease mechanisms. On the other hand, they require substantial funding and multidisciplinary skills. Therefore, basic biochemical/cell biology methods from molecular bioscience are still needed to address key biological questions. This new book uses the autoimmune disease Pemphigus Vulgaris (PV) as an experimental model of epidermal disease. Simple molecular bioscience principles and high-throughput methods to clarify disease pathophysiology are presented, which lead to novel therapeutic modalities. (Imprint: Nova Biomedical Press)

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Table of Contents:

1. Pathophysiology of the Epidermis: Lesson from pemphigus, pp. 1-20

2. Patients, sera, and experimental models, pp. 21-35

3. Optimization of the experimental procedures: Semi-quantitative LCIF microscopy, C-HSU buffer, and KAD medium, pp. 37-47

4. Study of Anti-desmoglein autoimmunity: Pemphigus as a desmoglein-remodeling disease, pp. 49-76

5. Role on non-desmoglein and non-igg in pemphigus, pp. 77-94

6. Downstream signaling involved in acantholysis: I. Changes in cell cycle and protein phosphorylation, pp. 95-109

7. Downstream signaling involved in acantholysis: II. Secretion of proteinases and the “specific proteolysis, pp. 111-122
hypothesis” of pemphigus

8. Microarray analysis of diseased tissues: Cell adhesion is down-regulated on the gene level in pemphigus, pp. 123-138

9. Pharmacological block of acantholysis: Towards novel therapies for the treatment of pemphigus, pp. 139-151


      Immunology and Immune System Disorders
      Dermatology - Laboratory and Clinical Research
   Binding: Softcover
   Pub. Date: 2011 2nd quarter
   Pages: 6 x 9 (NBC - C)
   ISBN: 978-1-61209-621-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Techniques in Epidermal Biology: An Integrated Approach to Autoimmune Skin Disease