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Matrix Metalloproteinases: Biology, Functions and Clinical Implications
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Editors: Namae Oshiro and Eiko Miyagi
Book Description:
Matrix metalloproteinases (MMPs) are a large group of zinc-dependent extracellular endopeptidase proteinases involved in the cleavage of extracellular matrix macromolecules. MMPs play an important role in normal physiology, migration of inflammatory cells and the repair process after tissue damage. In this book, the authors present current research in the study of the biology, functions and clinical implications of matrix metalloproteinases. Topics discussed include TGF-B and MMPs as a complex regulatory loop in tumor progression; MMPs role in the pathogenesis of osteoarthritis; gelatinases in the skin; detecting MMP activity in vivo; MMPs in renal fibrosis; macrophage migration inhibitory factor as a mediator of MMP production; MMP regulation by macrolides in cardiac disorders and MMPs in neural plasticity and disease. (Imprint: Nova Biomedical)

Table of Contents:
Preface

TGF-B and MMPs: A Complex Regulatory Loop Involved in Tumor Progression, pp. 1-37
(Miguel Quintanilla, Gael del Castillo, Jelena Kocic, Juan Francisco Santibáñez, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Spain, and others)

Matrix Metalloproteinases in Asthma, pp. 39-67
(Sittichai Koontongkaew, Orapan Poachanukoon, Thammasat University, Khlong Luang, Pratum Tani, Thailand)

Matrix Metalloproteinase: Role in the Pathogenesis of Osteoarthritis, pp. 69-98
(Sung Won Lee, Sang Yeob Lee, Won Tae Chung, Young Hyun Yoo, Division of Rheumatology, Department of Internal Medicine, and Mitochondrial Hub Regulation Center and Department of Anatomy and Cell biology, Dong-A University College of Medicine, Busan, Republic of Korea)

Gelatinases in the Skin, pp. 99-125
(Takashi Kobayashi, Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan)

Matrix Metalloproteinases, Memory, and Drugs of Abuse, pp. 127-150
(Barbara A. Sorg, Travis E. Brown, Translational Addiction Research Center, Alcohol and Drug Abuse Program and Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington, USA, and others)

Investigating Matrix Metalloproteinase Regulation in its Biological Context: Detecting MMP Activity in vivo, pp. 151-169
(Jonathan Y. Keow, Bryan D. Crawford, University of New Brunswick, Canada)

Matrix Metalloproteinases (MMPs) in Renal Fibrosis, pp. 171-188
(Guoping Zheng, Jianlin Zhang, Thian Kui Tan, Tzu-Ting Hsu, Xinrui Tian, Bo Niu, David C.H. Harris, Centre for Transplantation and Renal Research, Westmead Millennium Institute, The University of Sydney, Australia, and others)

Macrophage Migration Inhibitory Factor: A Mediator of Matrix Metalloproteinase Production, pp. 189-201
(Tadamichi Shimizu, Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan)

Short Communication:
Matrix Metalloproteinase Regulation by Macrolides in Cardiac Disorders, pp. 203-214
(Jun-ichi Suzuki, Masahito Ogawa, Kiyoshi Takayama, Yasunobu Hirata, Ryozo Nagai, Mitsuaki Isobe, Departments of a Advanced Clinical Science and Therapeutics and Cardiovascular Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo, Japan, and others)

The Role of Matrix Metalloproteinases in Neural Plasticity and Disease, pp. 215-224
(Kei-ichiro Yasunaga, Kazuo Emoto, Department of Cell Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan)

Index

   Series:
      Protein Biochemistry, Synthesis, Structure and Cellular Functions
   Binding: Hardcover
   Pub. Date: 2012
   Pages: 6 x 9 (NBC - R)
   ISBN: 978-1-62100-789-0
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Matrix Metalloproteinases: Biology, Functions and Clinical Implications