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Nitrous Oxide and Neurotransmission
Retail Price: $195.00
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Authors: Mark A Gillman (South African Brain Research Institute, Johannesburg, South Africa) 
Book Description:
As a lipid-soluble molecule, nitrous oxide enters the brain rapidly to alter the flow of information along a multitude of neuronal pathways and synapses by interfering with membrane ion channels and the action of key neurotransmitters. Some neurotransmitters, such as dopamine and the endogenous opioid peptides, act through G-protein coupled receptors mainly to adjust or modulate synaptic strength, whereas GABA and glutamate are amino acids known for their strong inhibitory or excitatory synaptic effects. Thus, nitrous oxide and nitric oxide belong to what now is becoming a sizable group of messenger molecules with signaling properties unlike any of the known non-gaseous chemical neurotransmitters. Indeed, the book discusses how research with nitrous oxide uncovered the new principle of gasotransmission. This book examines nitrous oxide and its effects on the various neurotransmitter systems and ion channels of the brain. This book also discusses how these effects could give rise to all the documented clinical actions of this relatively simple gas, including the most recently discovered application viz., the treatment of substance abuse withdrawal states. Throughout the book makes the important distinction between the neurotransmitter and clinical actions of nitrous oxide at low psychotropic analgesic concentrations and those associated with the much higher anaesthetic concentrations (Imprint: Nova)

Table of Contents:
Foreword

Preface

Chapter 1: Nitrous oxide and the endogenous opioid system (pp. 1-48)

Chapter 2: Nitrous oxide and the dopamine system (pp. 49-65)

Chapter 3: Nitrous oxide and the adrenergic system (pp. 67-87)

Chapter 4: Nitrous oxide and the Cys-loop superfamily systems (GABA, nicotinic acetylcholine, glycine and serotonin3) (pp. 89-115)

Chapter 5: Nitrous oxide and the glutaminergic system (pp. 117-137)

Chapter 6: Nitrous oxide and voltage-gated ion channels (pp. 139-161)

Chapter 7: Nitrous oxide, nitric oxide and neurotransmission (pp. 163-193)

Chapter 8: Clinical applications I Analgesia, anxiolysis and anaesthesia (pp. 195-229)

Chapter 9: Clinical applications II Treatment of substance abuse (pp. 231-277)

Index

   Series:
      Pain Management - Research and Technology
   Binding: Hardcover
   Pub. Date: 2012
   Pages: 7 x 10 294pp.
   ISBN: 978-1-61470-106-4
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Nitrous Oxide and Neurotransmission