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Rapamycin: Effectiveness, Safety and Drug Interactions
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Editors: Martin J. Blanco and Agustina M. Torres
Book Description:
Rapamycin is a macrocyclic natural product involved in various biological and pharmacological processes including antifungal, immunosuppressive, antitumor, neuroprotective and antiaging activities. In this book, the authors present current research in the study of the effectiveness, safety and drug interactions of rapamycin. Topics discussed include mTOR inhibitors in chronic liver diseases and cancer; rapamycin analogs temsirolimus and everolimus in the treatment of renal cancer; rapamycin control of multiple signalling pathways involved in cancer cell survival and drug resistance to rapamycin through elevated phospholipase D activity. (Imprint: Nova Biomedical)

Table of Contents:
Preface

mTOR Inhibitors in Chronic Liver Diseases and Cancer, pp. 1-30
(L. Bourgoin, N. Deblon, M. Peyrou, P. Ramadori, F. Rohner-Jeanrenaud, M. Foti, Department of Cell Physiology and Metabolism and Department of Internal Medicine, Division of Endocrinology, Diabetology and Nutrition, Faculty of Medicine, University of Geneva, Switzerland)

Starvation Profile of mTOR Inhibitors, pp. 31-52
(G. Aparicio Gallego, V. Medina Villaamil, L. León Mateos, L. Antón Aparicio, Medical Oncology, University Hospital, Santiago de Compostela, Spain, and others)

Identification of Candidate Biomarkers Predicting Response to Rapalogs Therapy in Human Cancer, pp. 53-67
(Ling-Hua Meng, Jian Ding, Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China)

Influence of Everolimus Drug Regime on Blood Cell Subsets in Kidney Transplant Patients, pp. 69-80
(N. Smit, F. Romijn, H. Dekter, Leiden University Medical Center, Department of Clinical Chemistry, The Netherlands)

The Emerging Mechanism of Limited Therapeutic Efficacy of Rapamycin for Cancers, pp. 81-91
(Yi Hu, Jing Liu, Qingsong Liu, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Cambridge, Massachusetts, USA, and others)

Rapamycin Controls Multiple Signalling Pathways Involved in Cancer Cell Survival, pp. 93-110
(Maria Fiammetta Romano, Simona Romano, Maria Mallardo, Rita Bisogni, Salvatore Venuta, Department of Biochemistry and Medical Biotechnology, University Federico II, Naples, Italy, and others)*

Drug Resistance to Rapamycin through Elevated Phospholipase D Activity, pp. 111-119
(David A. Foster, Department of Biological Sciences, Hunter College of the City University of New York, New York, USA)*

Index

   Series:
      Pharmacology - Research, Safety Testing and Regulation
      Organ Transplantation Research Horizons
   Binding: Softcover
   Pub. Date: 2012
   Pages: 6 x 9 (NBC - R)
   ISBN: 978-1-61942-642-9
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Rapamycin: Effectiveness, Safety and Drug Interactions