Book Description:
Recent clinical studies reported that in critically ill patients, oxidative stress caused by an increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and reduced antioxidant response is an expectable event. This book presents the actual scientific available evidence of the pathophysiology of oxidative stress and the role of it in different clinical situations in the critically ill patient, supporting an adjunct therapy to prevent the evolution to a multiple organ dysfunction syndrome. This point of view is supported by many recent clinical and experimental studies. (Imprint: Nova Biomedical)

Table of Contents:
Preface pp. i-viii

Chapter 1: Free Radicals: An Overview
(Osvaldo Berger, Faculty of Medicine, University of Chile)pp. 1-31

Chapter 2: Pathophysiology of Sepsis and Septic Shock
(Jazmina Bongain, Pediatric Intensive Care Unit, Doctor Roberto del Río Children´s Hospital, Santiago de Chile, Pediatrics and Intensive Care, University of Chile) pp. 33-49

Chapter 3: Inflammation
(Rodrigo Castillo, Pathophysiology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile) pp. 51-72

Chapter 4: Mitochondrial Dysfunction
(Víctor Molina, Faculty of Medicine, University of Chile) pp. 73-89

Chapter 5: Endothelial Dysfunction
(Emilia Sanhueza, Pathophysiology Program, Faculty of Medicine, University of Chile) pp. 91-114

Chapter 6: Pathophysiology of Multiple Organ Dysfunction Syndrome in Sepsis)
(Diego Saa and Ramón Rodrigo, Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile) pp. 115-133

Chapter 7: Nutrition in the Critically Ill Hospitalized Patient)
(Bettina von Dessauer, Pediatric Intensive Care Unit, Roberto del Río Children´s Hospital, Santiago de Chile, Pediatrics, University of Chile) pp. 135-153

Chapter 8: Contribution of Oxidative Stress in Pneumonia
(Rodrigo Carrasco, Faculty of Medicine, University of Chile)
pp. 155-169

Chapter 9: Oxidative Stress and Acute Respiratory Distress Syndrome
(Rodrigo Carrasco, and Cristian Carvajal, Faculty of Medicine, University of Chile and Pediatric Intensivist, Roberto del Río Children´s Hospital, Chile) pp. 171-194

Chapter 10: Oxygen Therapy and Oxidative Stress
(Bettina von Dessauer, and Jazmina Bongain, Pediatric Intensive Care Unit, Roberto del Río Children’s Hospital, Santiago de Chile, Pediatrics and Intensive Care, University of Chile) pp. 195-209

Chapter 11: Biomarkers of Oxidative Stress
(Rodrigo Castillo, Pathophysiology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile) pp. 211-237

Chapter 12: Exogenous Antioxidants as Potential Therapeutic Agents
(Ramón Rodrigo, Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile) pp. 239-260

Chapter 13: Myocardial Dysfunction
(Pedro Alvarez, Faculty of Medicine, University of Chile, Ana María Bañales, and Agustín Gatica, Intensive Care Unit. Metropolitan Hospital, Santiago, Chile) pp. 261-274

Index pp. 275-294