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Hypoxia: Causes, Types and Management
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Editors: Dirk Vordermark (Martin Luther University Halle-Wittenberg, Halle/Saale, Germany)
Book Description:
Low oxygenation levels are a hallmark of numerous pathologic conditions. Hypoxia occurs in chronic diseases of brain, kidneys and liver. Malignant tumors grow rapidly with insufficient vasculature, thereby producing areas of chronic hypoxia. This book contains contributions from an international group of authors covering a wide range of situations in benign as well as malignant diseases, in which understanding the role of hypoxia may lead to novel diagnostic and therapeutic strategies. These include modulation of tissue oxygenation as well as treatment concepts directed specifically at hypoxic cells. (Imprint: Nova Biomedical)

Please click on a chapter below to purchase separately

Chapter 1 - Hypoxia-induced damage to the adult and immature brain: molecular mechanism of oxidative damage and the need for targeted therapeutic intervention (pp. 3-20)
Authors / Editors: (Christian A. Reynolds, Maik Hüttemann, Karin Przyklenk, and Thomas H. Sanderson, Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI and others)

Chapter 2 - Chronic hypoxia, type 2 diabetes and Alzheimer’s disease: a dangerous triad (pp. 21-34)
Authors / Editors: (Cristina Carvalho, Renato X. Santos, Susana Cardoso, Sónia C. Correia, Paula I. Moreira, Center for Neuroscience and Cell Biology, University of Coimbra and others)

Chapter 3 - Molecular mechanisms of brain preconditioning (pp. 35-66)
Authors / Editors: (Jahan Ara, Melissa Frank, Department of Pediatrics, Drexel University College of Medicine and Saint Christopher's Hospital for Children, Philadelphia, PA)

Chapter 3 - Role of reactive oxygen and nitrogen species in the brain response to hypoxia: effect of parp-1 modulation (pp. 67-88)
Authors / Editors: (Siles E, Cañuelo A, Martínez-Romero R, Peinado MA, Martínez-Lara E, Department of Experimental Biology, University of Jaén, Paraje Las Lagunillas,Jaén, Spain)

Chapter 5 - Neonatal asphyxia and stroke: morbidity, models, consequences, and treatments (pp. 89-110)
Authors / Editors: (J. R. Rivers and J.C. Ashton, Department of Pharmacology and Toxicology, University of Otago,Dunedin, New Zealand)

Chapter 6 - Hypoxia and angiogenesis in the progression of chronic liver diseases towards cirrhosis and hepatocellular carcinoma (pp. 113-134)
Authors / Editors: (Stefania Cannito, Erica Novo, Chiara Busletta, Davide Povero, Claudia Paternostro, and Maurizio Parola, Dept. Experimental Medicine and Oncology – Interuniversity Center for Hepatic Pathophysiology, University of Torino, Torino Italy)

Chapter 7 - Effects of Physiological Hypoxia on Ovarian Corpus Luteum: Role of Hypoxia-Inducible Factor (HIF)-1α Signaling Pathway in Vascular Endothelial Growth Factor (VEGF)-Dependent Angiogenesis during Corpus Luteum Development (pp. 135-150)
Authors / Editors: (Zhengchao WANG, Provincial Key Laboratory for Developmental Biology and Neurobiology, College of Life Science, Fujian Normal University, Fuzhou, P. R. China and Dingzhong YIN, Laboratory of Animal Reproduction, Department of Animal Science, College of Animal Science and Technology, Anhui Science and Technology University, Bengbu, P. R. China)
***Open Access Chapter. Free Download Available***

Chapter 8 - Multifaceted roles of tubulointerstitial hypoxia in chronic kidney disease (pp. 151-168)
Authors / Editors: (Tetsuhiro Tanaka and Masaomi Nangaku, Division for Health Service Promotion, University of Tokyo and Division of Nephrology and Endocrinology, University of Tokyo School of Medicine)

Chapter 9 - Molecular mechanisms of hypoxia-mediated enhanced in vitro expansion, augmented self-renewal, and increased therapeutic potential of mesenchymal stem cells (pp. 169-182)
Authors / Editors: (Kenichi Tamama, Duk Soo Kim1, Svetoslava S. Kerpedjieva, Department of Pathology, University of Pittsburgh School of Medicine, PA and others)

Chapter 10 - Hypoxia and Hypoxia-Inducible Factor 1 in Venous Thrombosis (pp. 183-196)
Authors / Editors: (Colin E Evans, Julia Humphries, Alberto Smith, King’s College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at King’s Health Partners, Academic Department of Surgery, London, UK)

Chapter 11 - MiRNAs as mediators of cell response to hypoxia (pp. 197-208)
Authors / Editors: (Efimenko A.Yu., Klink G.V., Gluhanyuk E.V., Lopatina T.V., Kalinina N.I., Biological and Medical Chemistry Dept., Faculty of Basic Medicine, Moscow State University, Russia)

Chapter 12 - Causes and Management of hypoxia in solid tumor (pp. 209-222)
Authors / Editors: (Xiaoming Lia, Qingjia Suna, Ou Xua, Bethune International Peace Hospital; The First Hospital of Jilin University and The Second Hospital of Hebei Medical University, China)

Chapter 13 - Visualization and Treatment of the HIF-1-Active Microenvironments in Tumors: Drug Design and Application of Oxygen-dependent Degradable Probes for Molecular Imaging of HIF-1-active Microenvironments (pp. 223-236)
Authors / Editors: (Masashi Ueda, and Hideo, Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University and Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University)

Chapter 14 - Hypoxia in Micrometastases (pp. 237-254)
Authors / Editors: (Xiao-Feng Li and Yuanyuan Ma, Department of Diagnostic Radiology, University of Louisville School of Medicine, Louisville, KY, USA)

Chapter 15 - Osteopontin - an indicator of tumor hypoxia and treatment resistance (255-318)
Authors / Editors: (Christian Ostheimer and Dirk Vordermark, Dept. of Radiation Oncology, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany)

      Pulmonary and Respiratory Diseases and Disorders
   Binding: Hardcover
   Pub. Date: 2013- January
   Pages: 346, 7 x 10 (NBC - C)
   ISBN: 978-1-62081-769-8
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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