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Reassessing HIV Vaccine Design and Approaches: Towards a Paradigm Shift
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Authors: Omar Bagasra and Donald Gene Pace (Claflin University, South Carolina Center for Biotechnology, Office of International Study, Orangeburg, SC, USA) 
Book Description:
Why do we not have a vaccine for HIV? What are we doing wrong? Every HIV vaccine has failed so far, and public opinion is turning pessimistic against the scientific community. HIV vaccine efforts need a major shift in strategy. They require a better understanding of the immunological mechanisms that prevent African primates from getting AIDS. None of the 40 species of African primates, including chimpanzees and gorillas, get AIDS, even though all of them carry HIV-like viruses in their bodies. Why are they “naturally vaccinated,” while all of the man-made vaccines against HIV have failed miserably? This book offers intriguing new possibilities for the nature of human immunity, and the development of an effective AIDS vaccine. It is also a provocative treatise on the origin, evolution, and etiology of several forms of immune systems that is supported by a wealth of peer-reviewed scientific references. The compelling ideas presented in this study should have an important bearing on HIV vaccine development. It is a must read for anyone interested in the development of a safe AIDS vaccine, and for individuals interested in human immunity generally. (Imprint: Nova Biomedical)

Table of Contents:
Preface pp. i-xvii

Acknowledgements

CHAPTER 1: A Shift in the Current Concept of HIV Vaccine pp. 1-34

CHAPTER 2: Immunity: Old Paradigm Versus New pp. 35-66

CHAPTER 3: The Architecture of the Classical Immune System pp. 67-82

CHAPTER 4: Origins of HIV-1 pp. 83-112

CHAPTER 5: A Unified Concept of HIV Latency, Persistence and Reservoirs pp. 113-138

CHAPTER 6: Immune Activation and MicroRNA pp. 139-160

CHAPTER 7: GBV-C: A Natural HIV Interfering Virus pp. 161-180

CHAPTER 8: HIV Prevention and Compounding Factors in Chronic Progression to AIDS pp. 181-200

Epilogue pp. 201-202

References pp. 203-252

Index pp. 253-266

   Series:
      HIV/AIDS - Medical, Social and Psychological Aspects
      Virology Research Progress
   Binding: Hardcover
   Pub. Date: 2013- April
   Pages: 283, 7x10 - (NBC-C)
   ISBN: 978-1-62257-952-5
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Reassessing HIV Vaccine Design and Approaches: Towards a Paradigm Shift