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Glutathione: Biochemistry, Mechanisms of Action and Biotechnological Implications
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Editors: Nikolaos Labrou and Emmanouil Flemetakis (Laboratory of Enzyme Technology, Department of Agr. Biotechnology, Agricultural University of Athens, Athens, Greece)
Book Description:
Glutathione (ã-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol found in both prokaryotic and eukaryotic organisms. GSH has potent electron-donating capacity that renders GSH both a potent antioxidant and a conventional cofactor for enzymatic reactions. GSH participates in many cellular functions such as redox control, stress defense, drug detoxification and cell signaling including regulation of DNA and protein synthesis, gene expression, apoptosis and cell proliferation. GSH concentration in the cell is homeostatically controlled, being continually self-adjusting with respect to the balance between GSH synthesis, its recycling from GSSG and its utilization by other enzymes. Alterations in its concentration contribute to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases associated with redox processes modulation. This book discusses cutting-edge developments and deals with the information gained over the last few years on the physiological, biochemical and molecular roles of the GSH and its significance in mammalian, microbial and plant cells. (Imprint: Nova Biomedical)

Please click on a chapter below to purchase separately

Chapter 1 - Glutathione: Biosynthesis and Mechanism of Action (pp. 1-34)
Authors / Editors: (Érika Cristina Pavarino, Anelise Russo, Ana Lívia Silva Galbiatti, Wanda Pereira Almeida and Eny Maria Goloni Bertollo, São José do Rio Preto Medical School (FAMERP), Genetics and Molecular Biology Research Unit (UPGEM), Molecular Biology Department, São José do Rio Preto, Brazil and others)
***Open Access Chapter. Free Download Available***

Chapter 2 - Central Functions of Glutathione, and Peptides and Amino Acids related to Glutathione Synthesis and Metabolism, on Stress Responses (pp. 35-52)
Authors / Editors: (Mitsuhiro Furuse and D. Michael Denbow, Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan and others)

Chapter 3 - Glutathione: Disease-related Changes and Biomarkers of Oxidative Stress (pp. 55-76)
Authors / Editors: (Hugo Juárez Olguín and David Calderón Guzmán, Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), México and others)

Chapter 4 - Glutathione Studies and its Applicability in Animal Reproduction: An Alternative Therapy against Infertility? (pp. 79-94)
Authors / Editors: (Maria Madalena Pessoa Guerra, Sildivane Valcácia Silva and Diogo Ribeiro Câmara, Andrology Laboratory; Veterinary Medicine Department; Federal Rural University of Pernambuco, Recife, PE, Brazil and others)

Chapter 5 - The Significance of Astrocytic Glutathione System in Neuroprotection: A Potential Role for Circumin (pp. 95-110)
Authors / Editors: (Jagdeep K. Sandhu, Caroline Sodja, Angele Byrd, Christian Cadieux, Patricia Lanthier, P. Roy Walker and Marianna Sikorska, Neurogenesis and Brain Repair Group, Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada)

Chapter 6 - N-Acetylcysteine Amide (NACA), a Novel GSH Prodrug: Its Metabolism and Implications in Health (pp. 111-142)
Authors / Editors: (Shakila Tobwala and Nuran Ercal, Department of Chemistry, Missouri University of Science and Technology, Rolla, MO, USA)
***Open Access Chapter. Free Download Available***

Chapter 7 - Role of Glutathione in Infection and Cardiovascular Diseases (pp. 143-164)
Authors / Editors: (Dennis Gray, Beatrice Saviola, Frederick Guilford, Melissa Khurasany and Vishwanath Venketaraman, College of Osteopathic Medicine of the Pacific, Pomona, CA and others)

Chapter 8 - Glutathione and Glutathione S-Transferases: Risk Factors in Multifactorial Diseases (pp. 165-186)
Authors / Editors: (Ana Cristina Ramalhinho and Luiza Breitenfeld, CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, Covilhã, Portugal and others)

Chapter 9 - Structure and Catalytic Properties of Human Glutathione Transferase P1-1 (pp. 187-198)
Authors / Editors: (Evangelia Chronopoulou, Marianna Chatzikonstantinou, Panagiotis Madesis, Irini Nianiou-Obeidat and Nikolaos E. Labrou, Laboratory of Enzyme Technology, Department of Agricultural Biotechnology, Agricultural University of Athens, Athens, Greece and others)

Chapter 10 - Risk of Cancer associated with Measures of Placental Glutathione S-Transferase (GST-P7-7): A Comprehensive Review (pp. 199-206)
Authors / Editors: (Daniel Araki Ribeiro, Juliana Noguti, Augusto César, Camilo Dias Seabra Pereira, Rodrigo Brasil Choueri, Carla Cristina Medalha, Cristina dos Santos Cardoso de Sá, Rogério Aparecido Dedivits, Luis Fernando Barbisan and Regina Celia Spadari-Bratfisch, Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil and others)

Chapter 11 - Roles of Glutathione S-Transferases in Cancer and Aging: A Friend or Foe? (pp. 207-222)
Authors / Editors: (Misa Imai, Megumu Ito, Junwen Qin, Naomi Yamakawa and Yuji Takahashi, Department of Biochemistry, Tufts University School of Medicine, Boston, MA, USA and others)

Chapter 12 - Glutathione S-Transferase Gene Polymorphisms in Multiple Myeloma (pp. 223-230)
Authors / Editors: (Judit Várkonyi, Lívia Jánoskúti, Dóra Szakály, Barbara Újvári, Pál Pánczél, Nóra Hosszúfalusi, Peter Farkas, Gábor Mikala, Attila Tordai, Bernadette Schoket and István Karádi, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary and others)
***Open Access Chapter. Free Download Available***

Chapter 13 - Glutathione/Ascorbate Cycle and its Interrelation with Lipoic Acid: Could it Explain Why Plants do not Get Cancer? (pp. 233-262)
Authors / Editors: (Cristina Sgherri and Usue Pérez-López, Dipartimento di Biologia delle Piante Agrarie, University of Pisa, Pisa, Italy and others)

Chapter 14 - The Use of Highly Specific GSTs towards the Development of Stress Tolerant Transgenic Plants (pp. 263-274)
Authors / Editors: (Panagiotis Madesis, Irini Nianiou-Obeidat, Nikolaos E. Labrou and Athanasios Tsaftaris, Institute of Applied Biosciences, CERTH, Thessaloniki, Greece and others)

Chapter 15 - Glutathione: An Important Player in Plant-Microbe Interactions (pp. 275-292)
Authors / Editors: (Sotirios E. Tjamos and Emmanouil Flemetakis, Agricultural University of Athens, Greece)

Chapter 16 - Glutathione Metabolism in Protozoan Parasites: Making the Difference (pp. 295-326)
Authors / Editors: (Diego G. Arias, Vanina E. Márquez, Matías S. Cabeza, Alberto A. Iglesias and Sergio A. Guerrero, Instituto de Agrobiotecnología del Litoral (UNL – CONICET), FBCB Ciudad Universitaria Paraje “El Pozo”, Santa Fe, Argentina)

Chapter 17 - Glutathione and Programmed Cell Death in Kluyveromyces Lactis (pp. 327-340)
Authors / Editors: (Ana García-Leiro, Andreia S. Fernandes, Ana Castro, Arnaldo Videira, M. Esperanza Cerdán and M. Isabel González-Siso, Departamento de Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade da Coruña, Campus da Zapateira s/n, Spain and others)
***Open Access Chapter. Free Download Available***

Chapter 18 - Biotechnological Production of Glutathione in Yeast (pp. 341-354)
Authors / Editors: (Zhi-Qiang Xiong, Mei-Jin Guo and Ying-Ping Zhuang, Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China)

      Microbiology Research Advances
      Biochemistry Research Trends
   Binding: Hardcover
   Pub. Date: 2013- February
   Pages: 370, 7x10 - (NBC-C)
   ISBN: 978-1-62417-460-5
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Glutathione: Biochemistry, Mechanisms of Action and Biotechnological Implications