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Human Stefins and Cystatins
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Editors: Eva Zerovnik (Jožef Stefan Institute, Slovenia), Nataša Kopitar-Jerala and Vladimir Uversky (series editor)
Book Description:
This book brings up-to-date information on developments in studies of human stefins and cystatins, proteins with the function of cystein proteases (cathepsins) inhibition. The chapters start at the level of genes, go on with protein structure and function (proposal of alternative function), protein stability and folding, to mis-folding and mis-function. The book ends with chapters describing different disease states where stefins or cystatins are involved, from Alzheimer's disease, epilepsy to cancer.

Table of Contents:
Chapter Availability

Individual chapters are available for $25 each by sending an email to Nova will provide the chapter for your easy downloading or send it as an email attachment if you prefer.


Chapter 1. Human cystatins – Similarities, diversity and classification;
pp. 1-21
(Magnus Abrahamson, Carl-Michael Nathanson & Marcia Alvarez-Fernandez).

Chapter 2. Structural and protease inhibitory features of cystatins; pp. 23-42
(Marcia Alvarez-Fernandez & Magnus Abrahamson).

Chapter 3. Alternative functions for cystatin B implicated by its interaction with proteins other than proteases;
pp. 43-59
(Rossella Di Giaimo, Elena Cipollini, Massimo Riccio, Spartaco Santi, Martha Hoque, Maja Dembic, Pierpaolo Palmieri, Simona Carone & Marialuisa Melli).

Chapter 4. Conclusions on the mechanism of protein folding from stefins and cystatins studies;
pp. 61-73
(Eva Žerovnik, Manca Kenig, Jonathan P Waltho & Rosemary A Staniforth).

Chapter 5. Cystatin C domain-swapping and amyloid angiopathy: a general mechanism for the formation of amyloid fibrils ;
pp. 75-95
(Silva Giannini, Anna Sanders, Mariusz Jaskolski, Anders Grubb & Rosemary A. Staniforth).

Chapter 6. The mechanism of amyloid-fibrillation ; stefin B as a good model protein;
pp. 97-114
(Eva Žerovnik, Silva Giannini, Veronika Stoka, Magda Tušek-Žnidarič, Maruša Pompe-Novak & Rosemary A. Staniforth).

Chapter 7. Cystatin C role in Alzheimer disease: from neurodegeneration to neuroregeneration;
pp. 115-125
(Luisa Benussi*, Giuliano Binetti & Roberta Ghidoni).

Chapter 8. Cystatins in the cells of the immune system – a current
pp. 127-140

Chapter 9. Stefin B (cystatin B) as the gene whose deffect causes EPM1 syndrome;
pp. 141-152
(Sabina Rabzelj & Eva Žerovnik).

Chapter 10. Role of cystatins and stefins in cancer;
pp. 153-165
(Janko Kos & Tamara Lah).

Chapter 11. Cystatin C, a potential marker in various pathophysiological conditions;
pp. 167-187
(Nina Cimerman).


      Molecular Anatomy and Physiology of Proteins - Vladimir N. Uversky (Indiana University of Medicine, USA), Series Editor
   Binding: Hardcover
   Pub. Date: 2006
   ISBN: 1-60021-233-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Human Stefins and Cystatins