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Hematopoietic Stem Cell Transplantation Research Advances
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Editors: Karl B. Neumann
Book Description:
Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer.

Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease.

With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anesthesia to collect the graft.

Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases.

This new book presents recent leading research in the field.

Table of Contents:
Preface

Expert Commentaries

Commentary A - Mannan-Binding Lectin and Stem Cell Transplantation; pp. 1-6
(David C. Kilpatrick, Scottish National Blood Transfusion Service, Edinburgh, Scotland, U.K.)

Commentary B - Sexuality of Men Treated by Means of Haematopoietic Stem Cell Transplantation; pp. 7-13
(Ladislav Slovacek, Dept. of Field Internal Medicine, Faculty of Military Health Sciences, Univ. of Defence, Hradec Kralove, Czech Republic, Dept. of Clinical Oncology and Radiotherapy, Charles Univ. Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic, Birgita Slovackova, Dept. of Psychiatry, Charles Univ. Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic)

Research and Review Studies

Chapter I - Bone Marrow-Derived Stem Cells: Homing and Rescue of Injury in the Lung; pp. 15-43
(Donatella Piro, Silvia Lepore, Angela Bruna Maffione and Massimo Conese, Dept. of Biomedical Sciences, Univ. of Foggia, Foggia, Italy)

Chapter II - Role of Platelet Derived Factors for the Protection Against Graft-Versus-Host Disease; pp. 45-70
(Tsuyoshi Iwasaki, Division of Rheumatology and Clinical Immunology, Dept. of Internal Medicine, Hyogo College of Medicine, Mukogawa, Nishinomiya, Hyogo, Japan)

Chapter III - The Evolving Role of Hematopoietic Stem Cell Transplantation in Non-Hodgkin's Lymphoma; pp. 71-108
(Koji Kato, Smitha Mellacheruvu, Shin Mineishi, Blood and Marrow Transplantation Program, Univ. of Michigan, Comprehensive Cancer Center, MI)

Chapter IV - Stem Cell Plasticity; pp. 109-153
(Suraksha Agrawal, Piyush Tripathi, Dept. of Medical Genetics, Sita Naik, Dept. of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India)

Chapter V - Dental Management Before Hematopoietic Stem Cell Transplantation for Adult and Pediatric Patients with Hematological Disease; pp. 155-174
(Kenji Yamagata, Kojiro Onizawa, Hiroshi Yoshida, Dept. of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Univ. of Tsukuba, Tsukuba, Japan)

Chapter VI - Haematopoietic Stem Cell Transplantation and Quality of Life; pp. 175-198
(Ladislav Slovacek, Univ. of Defence, Faculty of Military Health Sciences, Dept. of Field Internal Medicine, Hradec Kralove, Czech Republic, Charles Univ. Hospital and Medical Faculty, Dept. of Clinical Oncology and Radiotherapy, Hradec Kralove, Czech Republic, Birgita Slovackova, Charles Univ. Hospital and Medical Faculty, Dept. of Psychiatry, Hradec Kralove, Czech Republic)

Chapter VII - Risk Factors for Survival in Pediatric Patients Undergoing Allogeneic Cord Blood Transplantation; pp. 199-213
(Marta Gonzalez-Vicent, Julian Sevilla, Alvaro Lassaletta, Hospital Nino Jesus, Madrid, Spain)

Chapter VIII - Multipoptent Mesenchymal Stromal Cells for Skin Wound Healing and Skeletal Muscle Repair; pp. 215-227
(Ying Zhu, Chunmeg Shi, Xinze Ran, Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, College of Preventive Medicine, Third Military Medical Univ., Chongqing, China)

Index

   Series:
      Stem Cells - Laboratory and Clinical Research
   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 978-1-60456-042-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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