Book Description:
Today, cancer is the second most prevelant cause of death, after heart disease, in the industrialized world. Till now, and despite promising results in cancer research, the primary cause of death in cancer is still 1: the formation of metastases at distant organs sites, 2: the presence of cancer cells that are resistant to current cancer therapies (chemotherapy/radiation) and which cause cancer relapse. Within the past three years it became evident that also solid tumor tissues contain a kind of stem cells, so-called cancer cells. These cancer stem cells have been described as chemo-/radiation therapy resistant tumor initating cells. The purpose of this book is to summarize the latest findings about the role of stem cells in cancer.

We’ve partnered with Copyright Clearance Center to make it easy for you to request permissions to reuse Nova content.
For more information, click here or click the "Get Permission" button below to link directly to this book on Copyright Clearance Center's website.

Table of Contents:
Preface pp.i-viii

Chapter 1. Cancer Stem Cells: A Definition;pp. 1-10
(Jichao Qin, Department of Carcinogenesis, University of Texas M.D Anderson Cancer Center, Science Park-Research Division, Smithville, TX, Dean G. Tang, Department of Carcinogenesis, University of Texas M.D Anderson Cancer Center, Science Park-Research Division, Smithville, TX, Program in Molecular Carcinogenesis, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center, Houston, TX, USA)

Chapter 2. Mathematical Modeling of Stem Cells Related to Cancer;pp. 11-36
(Monika Joanna Piotrowska, Inst. of Mathematics, University of Witten/Herdecke, Germany, Institute of Applied Mathematics and Mechanics, Warsaw University, Poland, Heiko Enderling, Caritas St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, USA, Uwe an der Heiden, Inst. of Mathematics, University of Witten/Herdecke, Stockumer Str., Germany, et al.)

Chapter 3. Where Do Cancer Stem Cells Come From?;pp. 37-49
(Calin Stoicov and JeanMarie Houghton,University of Massachusetts Medical School, Worcester, MA)

Chapter 4. Mismatch Repair Deficiencies and Origin of Cancer Stem Cells;pp. 50-68
(Minal Garg. Department of Biochemistry, University of Lucknow, India)

Chapter 5. Cancer Stem Cells in Hematological Malignancies;pp. 69-86
(Aniruddha J. Deshpande and Christian Buske, Helmholtz Center for Environment and Health and the Clinical Cooperative Group- Leukemia, Department of Medicine III, Munich, Germany)

Chapter 6. Stem Cells in Solid Tumors;pp. 87-110
(Andres Matoso and Alexander Yu. Nikitin, Department of Biomedical Sciences, Cornell University, Ithaca, NY)

Chapter 7. Cancer Stem Cells and Metastasis;pp. 111-126
(Benjamin Tiede and Yibin Kang, Department of Molecular Biology, Princeton University, Princeton, NJ)

Chapter 8. Exercise, Stem Cells and Cancer;pp. 127-146
(Emre Tunca, Karsten Krüger, Frank C. Mooren, Department of Sports Medicine, Inst. of Sports Sciences, Justus-Liebig-University, Giessen, Germany)

Chapter 9. Human Adult Stem Cells as Targets for Cancer Stem Cells: Evolution: Oct-4 Gene and Cell to Cell Communication;pp. 147-188
(James E. Trosko, Center For Integrative Toxicology, National Food Safety Toxicology Center, College of Human Medicine, Michigan State University, Michigan)

Chapter 10. Targeting Cancer Stem Cells;pp. 189-198
(Thomas Dittmar and Kurt S. Zänker, Institute of Immunology, Witten/ Herdecke University, Germany)

Index pp.199-220