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Clinical, Genetic and Molecular Precursor Features in Colorectal Neoplasia
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Editors: Kjetil Søreide (Department of Pathology, Stavanger University Hospital, Department of Surgery, Stavanger University Hospital, The Gade Institute, University of Bergen, Bergen, Norway), Håvard Søiland (Department of Surgery, Stavanger University Hospital)
Book Description:
The understanding of the mechanisms that explain the initiation and early evolution of colorectal cancer is evolving. This should facilitate the development of new approaches to effective prevention and intervention. Over the past years, deficiencies in the current adenoma-carcinoma model for colorectal cancer, in which APC mutation is placed at the point of initiation, have been suggested. Several pathways through which cancer may develop seem to exist, such as ‘chromosomal instability’ (CIN), ‘microsatellite instability’ (MSI), and most recently the ‘serrated pathway’ involving epigenetic changes. Parallel to discoveries in molecular pathways are the increased awareness of early and precursor features of the colorectal mucosa detected and treated by endoscopic and minimal-invasive techniques. Thus, new staging and classification systems have been developed to guide the clinician in diagnosis and choice of treatment.This book sets focus on selected clinical and molecular aspects of colorectal precursor lesions; from the endoscopically detected colorectal polyp, major molecular mechanisms, and aspects of protease-systems in colorectal cancer development. Future research on colorectal cancer needs to be stratified according to the appropriate clinical features and their associated genetic pathways involved in order to further explore important molecular mechanisms and clinicopathological consequences of chromosomal, microsatellite and epigenetic mechanisms.

Table of Contents:
Preface

I. Introduction

II. Colorectal Carcinogenesis

III. Hereditary Colorectal Cancers

IV. Inflammation and Colorectal Cancer

V. Early Colorectal Cancer

VI. Microsatellite Instability

VII. Epigenetic Silencing

VIII. Cyclooxygenase-2 and Colorectal Neoplasia

IX. Trypsin in Colorectal Cancer

X. Other Proteinase-Systems

XI. Conclusions

References

Index

   Series:
      Cancer Etiology, Diagnosis and Treatments
   Binding: Softcover
   Pub. Date: 2008
   ISBN: 978-1-60456-714-4
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Clinical, Genetic and Molecular Precursor Features in Colorectal Neoplasia