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Horizons in Neuroscience Research. Volume 1
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Editors: Andres Costa and Eugenio Villalba
Book Description:
Neuroscience is the scientific study of the nervous system. The principle mechanism underlying enhanced pain sensitivity is a persistent hyperexcitability of spinal dorsal horn neurons. This book describes cellular mechanisms for the maintained hyperexcitability of spinal dorsal horn neurons mediated by neuron-glia interactions following spinal cord injury. In addition, nerve growth factor (NGF) has a key role not only in the development of sensory and autonomic neurons, but also in the processes of nociception. This book examines the recent evidence of the involvement of NGF in painful diseases and suggests the potential usefulness of anti-NGF strategies as novel analgesics for disabling pathological conditions. Furthermore, neuralgia is a symptom of some neurological disorders and can be found at any age. The pain that accompanies it is usually brief but may be severe. The authors present evidence sustaining the hypothesis that neuralgia (understood as being a shooting/shock-like paroxysmal pain) is a clinical expression of a transcriptional channelopathy. Other chapters in this book review the underlying mechanisms and the anatomical loci/shared circuits between epilepsy and memory, along with the relationship of various neurotransmitters involved. The morphological and functional characteristics of hereditary choroidal dystrophies are also examined, as well as the potential implications of neuroplasticity in dorsal vagal complex (DVC) in the adaptation of gastrointestinal functions.

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Table of Contents:
Preface

Chapter 1. Nervous, Immune, Endocrine Regulatory Systems and Diseases Associated with Nerve Growth Factor Co-Secretion, pp. 1-96
(Ildikó Molnár, Immunoendocrinology, EndoMed, Debrecen,Hungary)

Chapter 2. Nerve Growth Factor and Pain: Evidence from Experimental Models and Humans, and New Prospectives for Treatment, pp. 97-132
(Paola Sarchielli, Katiuscia Nardi, Stefano Caproni, Davide Chiasserini, Giuseppe Capocchi, Paolo Calabresi, Neurologic Clinic, Department of Medical and Surgical Specialities and Public Health, University of Perugia, Italy and others)

Chapter 3. Homeostatic Role of the Parasympathetic Nervous System in Human Behavior, pp. 133-159
(Aurélien Pichon, Didier Chapelot, Laboratoire des Réponses Cellulaires et Fonctionnelles à l'Hypoxie, Université Paris, Bobigny, France)

Chapter 4. LIMK1: The Key Enzyme of Actin Remodeling Bridges Spatial Organization of Nucleus and Neural Transmission: From Heterochromatin via Non-Coding RNAs to Complex Behavior, pp. 161-193
(Anna V. Medvedeva, Alexander V. Zhuravlev, Elena V. Savvateeva-Popova, Pavlov Institute of Physiology Russian Academy of Sciences)

Chapter 5. “Gliopathy” Maintains Persistent Hyperexcitability of Spinal Dorsal Horn Neurons after Spinal Cord Injury: Substrate of Central Neuropathic Pain, pp. 195-224
(Young S. Gwak and Claire E. Hulsebosch, Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, TX)

Chapter 6. Multiple Neuronal and Glial Mechanisms Can be Involved in the Response to the Activation of Nicotinic Receptors, pp. 225-256
(A. Toledano, M. I. Alvarez, A. Toledano-Díaz, Instituto Cajal, C.S.I.C. Madrid. Spain, and others)

Chapter 7. Calcium Signaling in Glial Cells of the Enteric Nervous System, pp. 257-272
(Weizhen Zhang, Michael W. Mulholland, Dept. of Surgery, University of Michigan, Ann Arbor, Michigan, and others)

Chapter 8. Cocaine and Craving: From Normal Transmission to Pathological Functioning, pp. 273-288
(Paul G. Overton, Ian M. Devonshire, Department of Psychology, University of Sheffield, Sheffield, UK, and others)

Chapter 9. pilepsy and Cognitive Functions: An Inverse Relationship of the Underlying Mechanisms, pp. 289-304
(Razia Khanam, Divya Vohora, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India)

Chapter 10. Pathogenesis of Sciatica: Intraradicular Blood Flow Analysis under the Tension of Nerve Root Induced by Lumbar Disc Herniation, pp. 305-321
(Shigeru Kobayashi, Hisatoshi Baba, Takafumi Yayama, Kenzo Uchida, Kenichi Takeno, Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Shimoaizuki, Matsuoka, Fukui, Japan)

Chapter 11. Hereditary Choroidal Dystrophies, pp. 323-339
(Márta Janáky, Department of Ophthalmology, Faculty of Medicine, University of Szeged, Szeged, Hungary)

Chapter 12. Neuroplasticity in the Dorsal Vagal Complex, pp. 341-354
(Weizhen Zhang, Michael W. Mulholland, Peking University Health Science Center, Beijing, China, and others)

Chapter 13. agus Nerve Stimulation in Food Intake Control, pp. 355-366
(I. Díaz-Güemes Martín-Portugués, F. M. Sánchez Margallo, L. Luis Fernández, J. Usón Gargallo, Centro de Cirugía de Mínima Invasión “Jesús Usón”, Cáceres, Spain)

Chapter 14. Amino Acid-Sensing by the Abdominal Vagus, pp. 367-377
(A. Kitamura, A. Niijima, K. Torii, H. Uneyama, Physiology and Nutrition Group, Institute of Life Sciences, Ajinomoto Co., Inc. Kawasaki, Japan, and others)

Chapter 15. Proteomics Helps to Elucidate the Causes of Schizophrenia, pp. 379-389
(Daniel Martins-de-Souza, Max Planck Institute for Psychiatry, Munich, Germany)

Chapter 16 Is Neuralgia a Transcriptional Channelopathy?, pp. 391-396
(Ángela M. Gutiérrez-Álvarez, Carlos B. Moreno, NEUROS Research Group, School of Medicine, Universidad del Rosario, Bogotá, Colombia)

Index

   Series:
      Horizons in Neuroscience Research
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 434 pp.
   ISBN: 978-1-60692-068-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Horizons in Neuroscience Research. Volume 1