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Small Interfering RNA: New Research
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Editors: Kaito Yamada and Shouta Hayashi
Book Description:
RNA interference is a gene silencing phenomenon triggered by dsRNA (double-stranded RNA) and has been widely used for studying gene functions. The short interfering RNA (siRNA) responsible for RNA interference varies markedly in its gene silencing efficacy. This book reviews the recently reported siRNA design guidelines and clarifies the problems concerning the guidelines. An effective method for selecting siRNA target sequences from many possible candidate sequence is also described by using Bayes' theorem. Furthermore, the development of a durable RNAi therapy for cancer and viral infections, which may require the use of multiple inhibitors is evaluated. This book also reviews the structure, application and therapeutic challenges of siRNA.

Table of Contents:
Preface pp.i-xii

Chapter 1. Silencing Persistent Virus Infections by RNA Interference, pp.1-36
(Florence Colbere-Garapin, Annette Martin, Aure Saulnier, Isabelle Pelletier, Arnaud Autret, Cynthia Brisac, and Bruno Blondel)

Chapter 2. An Effective Method For Selecting siRNA Sequences By Using Bayes' Theorem, pp.37-64
(Shigeru Takasaki)

Chapter 3. Short Interfering RNA For Antiviral Treatment, pp.65-84 (Sha Jin and Kaiming Ye)

Chapter 4. Combinatorial RNAi Approaches: Killing 1 Bird With 2 Stones, pp.85-100
(Ying Poi Liu and Ben Berkhout)

Chapter 5. RNAi, a Powerful Research Tool and Potential Molecular Therapy for Liver Diseases, pp.101-120
(Jin-Wook Kim and Jian Wu)

Chapter 6. Methylation and Loss of Heterozygosity in Cancer are linked by siRNA?, pp.121-154
(Coral Wynter, Marcelo Alfonso, and Maria Fernanda Correa)

Chapter 7. Biodegradable Poly(B-Amino Ester) Derivatives for Gene and siRNA Delivery, pp.155-184
(Dhananjay Jere, Rhohidas Arote and Chong-Su Cho)

Chapter 8. Experimental Validation of Published siRNA Design Algorithms, pp.185-194
(Yuki Naito, Kaoru Saigo and Kumiko Ui-Tei)

Chapter 9. Optimal siRNA Sequence Design for RNA Interference, pp.195-224
(Shigeru Takasaki)

Chapter 10. In vivo siRNA Delivery through Polymers-Based Nanoparticles, pp.225-242
(Achim Aigner)

Index pp.243-265

      Nucleic Acids: Chemical Structure, Types and Components
   Binding: Hardcover
   Pub. Date: 2009
   Pages: 277
   ISBN: 978-1-60692-158-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Small Interfering RNA: New Research