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Ribosomal Proteins and Protein Engineering: Design, Selection and Applications
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Editors: Valter Ortendhal and Hjalmar Salchow
Book Description:
Ribosome is an important cellular organelle that is necessary for the basic cellular process, protein synthesis. Furthermore, ribosomal protein is a group of proteins that is important in biomedical research. The authors of this book present and review important data on ribosomal proteins, important in tropical diseases such as malaria and tuberculosis. In addition, some functions of ribosomal proteins, other than translation, are called extraribosomal function or extraribosomal activity. In this book, the extraribosomal functions of ribosomal protein S19 (RPS19) is discussed in detail. Other chapters in this book examine the structures of the free and bound forms of proteins that have experimentally been found to be essential for the first steps of ribosome assembly. A summary of ribosomal protein mutations generated in eukaryotes is also provided and their proposed roles in the control of cell growth and proliferation, as well as their impact in human diseases. Important challenges we face in explaining life from the genome and proteome viewpoint is also discussed, including how to measure a living protein/RNA/DNA, how to restore the missing relation cross generations and how to correlate structure with function. Finally, the authors suggest possible solutions for such challenges.



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Chapter 1 - DESIGNING NON-CLASSICAL INCLUSION BODIES pp. 1-20
Authors / Editors: (Špela Peternel, Department of Biosynthesis and Biotransformation, National Institute of Chemistry, Ljubljana, Slovenia)

Chapter 2 - EXTRARIBOSOMAL FUNCTIONS OF RIBOSOMAL PROTEIN S19” IN MONOGRAPH RIBOSOMAL PROTEINS pp. 21-39
Authors / Editors: (Tetsuro Yamamoto, Hiroshi Nishiura, Department of Molecular Pathology, Kumamoto Univ. Graduate School, Kumamoto, Japan)

Chapter 3 - ORDER-DISORDER TRANSITIONS IN RIBOSOME ASSEMBLY pp. 41-54
Authors / Editors: (Youri Timsit, Frederic Allemand, Claude Chiaruttini, Mathias Springer, Laboratoire de Cristallographie et de Biochimie Theorique, Paris, France and others)

Chapter 4 - DISRUPTION OF RIBOSOMAL PROTEIN GENE EXPRESSION IN EUKARYOTES: A CLASS OF MUTATIONS CAUSING SIMILAR GLOBAL GROWTH DEFECTS WITH CELLULAR VARIATIONS pp. 55-63
Authors / Editors: (Catherine Kirn-Safran, Dept. of Biological Sciences, Univ. of Delaware, Newark, DE, USA)
***Open Access Chapter. Free Download Available***

Chapter 5 - ANCESTRAL PROTEIN RECONSTRUCTION AS A NEW FIELD IN PROTEIN ENGINEERING pp. 65-90
Authors / Editors: (Ayumu Konno, Tomohisa Ogawa, and Tsuyoshi Shirai, Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University, Sendai 980-8575, Japan, and others)

Chapter 6 - RIBOSOMAL PROTEINS IN IMPORTANT TROPICAL DISEASES pp. 91-98
Authors / Editors: (Viroj Wiwanitkit - Wiwanitkit House, Bangkhae, Bankok, Thailand)

Chapter 7 - THREE CHALLENGES IN POST-PROTEOMICS TIME pp. 99-102
Authors / Editors: (Shaomin Yan, Guang Wu, Guangxi Academy of Sciences, Nanning, Province Guangxi, China and others)

Chapter 8 - SELF-SIMILAR PROPERTYOF RIBOSOMAL PROTEINS pp. 103-119
Authors / Editors: (Chang-Yong Lee, Dept. of Industrial and Systems Engineering, Kongju National Univ., Kongju, South Korea)

Chapter 9 - SYNTHESIZING MAMMALIAN CELL ADHESIVE SURFACES USING SELF-ASSEMBLING FIBRONECTIN DOMAINS pp. 121-141
Authors / Editors: (Patricia Pereira, Christopher F. van der Walle, Research Institute for Medicines and Pharmaceutical Sciences, Faculdade de Farmácia, Edifício E, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa, Portugal, and others)

Chapter 10 - HALOPHILIC ADAPTATIONS OF PROTEINS pp. 143-174
Authors / Editors: (Albert Bolhuis,Daniel Kwan, and Judith R. Thomas, Dept. of Biological Sciences, Univ. of Warwick, UK)

Chapter 11 - ALKALINE ADAPTATION OF PROTEINS pp. 175-210
Authors / Editors: (Tsuyoshi Shirai, Nagahama Inst. of Bio-science and Technology, Japan; Tohru Kobayashi and Koki Horikoshi, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Japan; Susumu Ito, CRIS, Hokkaido Univ., Japan)

   Series:
      Protein Science and Engineering
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 7 x 10, 222 pp.
   ISBN: 978-1-60741-005-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Ribosomal Proteins and Protein Engineering: Design, Selection and Applications