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Molecular Pathology of Proteins
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Editors: D.I. Zabolotny ( A.S. Kolomychenko Institute of Otolaringology, Kiev, Ukraine)
Book Description:
The new and important book is attempt to clarify some structural and functional protein disfunctions that are related with molecular pathologies. These consist of a wide group of diseases, which are induced by the disruption of the normal physiological processes because of the inability of some proteins to take part into inter-molecular interactions mediating these processes. It presents materials concerning autoimmune, folding and genetic pathologies, problems of the ensuring of functional activity of the protein preparations and biocompatibility of medical implants.

Table of Contents:
Preface

Chapter 1. Inter-molecular coordination of proteins at normal and pathologic state;pp. 1-21
(Zabolotny, D.I., Verevka, S.V.)

Chapter 2. The problems of protein preparations stability: molecular autodamages and their functional consequences;pp. 23-30
(Shevel, M.V., Verevka, S.V.)

Chapter 3. Autoimmune processes and their clinical Significance;pp. 31-40
(Chernushenko, E.F.)

Chapter 4. Hemophilia, Aggravated by the Inhibitor;pp. 41-55
(Stasyshyn A.V.)

Chapter 5. Molecular chaperones under normal and pathological conditions;pp. 57-89
(Marchenko, N.Yu., Garbuzinskiy, S.A., Semisotnov, G.V.)

Chapter 6. Genetic polymorphysm of immunoproteasome and its functional significance;pp. 91-102
(Dosenko V.E., Goldenberg D.I.)

Chapter 7. Endoplasmic Reticulum Stress as the Universal mechanism of Cellular response unfolded Proteins;pp. 103=113
Tumanovskaya, L.V., Nagibin, V.S., Dosenko, V.E.)

Chapter 8. Genetic polymorphysm of alpha-1-inhibitor of proteinases and its clinical significance;pp. 115-126
(Zabolotny D.I., Kizim A.Y., Goloborodíko O.P., Karpenko G.F.)

Chapter 9. Addressing the question of the role of proteolytic enzymes and their inhibitors in the pathogenesis of diabetes mellitus;pp. 127-138
(Dosenko, V.E., Goldenberg, D.I.)

Chapter 10. Proteolytically degraded enzymes derivatives: Their diagnostic and therapeutic value;pp. 139-151
(Klysí, Yu.G., Storchak R.M., Verevka S.V.)

Chapter 11. Activating action of Streptokinase and its role in the injury pf Immune Homeostasis;pp. 153-158
(Kurkina, T.V., Sambur, M.B., Verevka, S.V.)

Chapter 12. The contact denaturation of the proteins and the problem of biocompatibility of implants;pp. 159-168
(Savchuk, A.N., Zinchenko, D.I., Zabolotny, D.I.)

Conclusion;pp. 169
Data about the authors;pp. 171-172
Index

   Series:
      Protein Biochemistry, Synthesis, Structure and Cellular Functions
   Binding: Hardcover
   Pub. Date: 2009
   Pages: 191 pp.
   ISBN: 978-1-60741-020-1
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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