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Serpins and Protein Kinase Inhibitors: Novel Functions, Structural Features and Molecular Mechanisms
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Editors: Bojidor Georgiev and Sava Markovski
Book Description:
Serpins, a group of proteins with similar structures, were first identified as a set of proteins able to inhibit proteases. The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation and inflammation. Today, over 1000 serpins have been identified, including 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors. In contrast, a protein kinase inhibitor is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Protein tyrosine kinases (PTKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration and survival. Due to their involvement in various forms of cancer, PTKs have become prominent targets for therapy. This new book gathers the latest research from around the globe in this dynamic field.

Please click on a chapter below to purchase separately

Chapter 1 - Serpin-Related Diseases pp.1-36
Authors / Editors: (Aleksandra Topic—Institute of Medical Biochemistry, Faculty of Pharmacy, Belgrade, Serbia)

Chapter 2 - The Roles of Mammalian Mitogen-Activated Protein Kinase-Activating Protein Kinases (MAPKAPKs) in Cell Cycle Control pp.27-62
Authors / Editors: (Sergiy Kostenko, Alexey Shiryaev, Nancy Gerits, Ugo Moens - Univ. of Tromso, Faculty of Medicine, Institute of Medical Biology, Dept. of Microbiology and Virology, Tromso, Norway)

Chapter 3 - Rho-Kinase Inhibitor in Kidney Disease pp.63-88
Authors / Editors: (Toshio Nishikimi - Dept. of Hypertension and Cardiorenal Medicine, Dokkyo Medical Univ., Mibu, Japan)

Chapter 4 - Targeting the Epidermal Growth Factor Receptor Pathway in Glioblastoma Multiforme and Other Intracranial Malignancies pp.89-106
Authors / Editors: (Marc-Eric Halatsch, Georg Karpel-Massler - Dept of Neurosurgery, Univ. of Heidelberg, Heidelberg, Germany)

Chapter 5 - The Serine Proteinase Inhibitor Z Alpha-1 Antitrypsin: Acting on the NF-kappaB System for Cytotoxicity pp.107-124
Authors / Editors: (Matthew William Lawless, Department of Clinical Medicine, Trinity College, Dublin, St. James Hospital, Ireland)

Chapter 6 - Src Family Kinase Inhibitors in Cancer Therapy pp.125-152
Authors / Editors: (Faye M. Johnson, Gary E. Gallick - Dept. of Thoracic/Head and Neck Medical Oncology, The Univ. of Texas, Houston, TX, and others)

Chapter 7 - Protein Kinase Inhibitors in Cancer pp.153-166
Authors / Editors: (Yiguo Hu, Shaoguang Li - The Jackson Laboratory, Bar Harbor Maine)

Chapter 8 - Protein Kinase Inhibitors: New Research pp.167-182
Authors / Editors: (Panagiotis Samaras, Frank Stenner - Department of Oncology, Univ. Hospital Zurich, Raemistrasse, Switzerland)

Chapter 9 - PAI-1 and the Diet-Induced Obesity Phenotype: Background Effects and Inbreeding pp.183-198
Authors / Editors: (Bart M. De Taeye, Tatiana Novitskaya, and Douglas E. Vaughan, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN)

Chapter 10 - The Structure of á1-Proteinase Inhibitor Polymer: Facts and Hypothesis pp.199-210
Authors / Editors: (Ewa Marszal—Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland)
***Open Access Chapter. Free Download Available***

Chapter 11 - SERPINA5 Expression in the Male Reproductive Tract is altered with Advanced Age pp.211-218
Authors / Editors: (Matthew D Anway—Center For Reproductive Biology, Department of Biological Sciences, University of Idaho, Moscow, ID)

Chapter 12 - Vaspin: Visceral Adipose Tissue-Derived Serpin with Insulin-Sensitizing Effects pp. 219-228
Authors / Editors: (Jun Wada —Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan

Chapter 13 - Effect of Alpha2-Antiplasmin on Tissue Remodeling pp. 229-235
Authors / Editors: (Yosuke Kanno and Hiroyuki Matsuno—Dept. of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, Doshisha Women’s Collage of Liberal Arts, Kyoto, Japan)

      Protein Biochemistry, Synthesis, Structure and Cellular Functions
   Binding: Hardcover
   Pub. Date: 2009
   Pages: pp.257
   ISBN: 978-1-60741-187-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Serpins and Protein Kinase Inhibitors: Novel Functions, Structural Features and Molecular Mechanisms