Book Description:
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Frequently, resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells. Studies on the mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and its implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.

Table of Contents:
Preface

Therapeutic Implications of the Intrinsic and Acquired Resistance of Cancer Stem/Progenitor Cells in Inefficacy of Current Cancer Treatments and Disease Relapse;pp. 1-32
(Murielle Mimeault and Surinder K. Batra, Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska)

Role of O6-methyl guanine-DNA methyl transferase and the effect of O6-benzylguanine in cancer chemotherapy;pp. 33-71
(Jun Murakami, Jun-ichi Asaumi, Hidetsugu Tsujigiwa, Masao Yamada, Susumu Kokeguchi, Hitoshi Nagatsuka, Tatsuo Yamamoto, You-Jin Lee, 1Department of Oral and Maxillofacial Radiology, Okayama University, Okayama, Japan, et al.)

The Role of Tumoural Micro-Environment and its Vasculature on Chemotherapy Drug Resistance: The Potential for it's Modulation to Achieve Therapeutic Gain;pp. 73-94
(A. Weickhardt, M. Michael, Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia)

Inherent and Microenvironment-Mediated Mechanisms of Drug Resistance;pp. 95-112
(Malathy P.V Shekhar, Breast Cancer Program, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan)

Studies on the Mechanisms of Acquired Resistance to EGFR Tyrosine Kinase Inhibitor Gefitinib in NSCLC Cell Lines: Evidence that Ligand-Induced Endocytosis of EGFR via the Early/Late Endocytic Pathway is Associated with Gefitinib Sensitivity of NSCLC Cell Line;pp. 113-131
(Yukio Nishimura, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan)

Mechanisms of resistance to EGF receptor-tyrosine kinase inhibitor in NSCLC cell lines: Gefitinib sensitivity is closely correlated with ligand-induced endocytosis of phosphorylated EGF receptor;pp. 133-148
(Yukio Nishimura, Kiyoko Yoshioka, Kazuyuki Itoh, 1Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, and others)^

Targeting Adverse Features of Hormone-Resistant Breast Cancer;pp. 149-164
(Stephen Hiscox, Liam Morgan, Nicola Jordan, Julia Gee, Robert I Nicholson, Welsh School of Pharmacy, Cardiff University, Cardiff, UK)

Systematic Analysis of Patterns of Cross Resistance between Anticancer Agents;pp. 165-174
(Britta Stordal and Ross Davey, National Institute for Cellular Biotechnology, Dublin City University, Ireland, and others)

Molecular Structure and Energy: Clinical Importance in Drug Resistant Neoplasms;pp. 175-180
(Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok, Thailand)

Treating Drug Resistant Malignancy;pp. 181-186
(Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok, Thailand)

Overcoming Ovarian Cancer Drug Resistance with Phytochemicals and Other Compounds;pp. 187-216
(Marion M. Chan, Temple Univ. School of Medicine, Dept. of Microbiology and Immunology, Philadelphia, PA, Dunne Fong, The State Univ. of New Jersey, Dept. of Cell Biology and Neuroscience, Piscataway, NJ)*

New Research Communications on Cancer Drug Resistance, Assessment of cancer drug resistance with nuclear medicine images;pp. 217-231
(Seigo Kinuya, Dept. of Biotracer Medicine,Kanazawa University Graduate School of Medical Sciences,Kanazawa,Japan)

Index