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Sperm Nuclear Maturation: A Basic and Clinical Approach
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Authors: Ali Reza Talebi (Shahid Sadoughi Medical University, Yazd, Iran) 
Book Description:
In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure. Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed `sperm chromatin condensation'. This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.

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Table of Contents:

Part I. Mechanism of Sperm Nuclear Remodeling, pp.1-16

Part II. The Origin of Sperm Chromatin/DNA Damages, pp.17-34

Part III. Factors Affecting Sperm Chromatin and DNA Structure, pp.35-44

Part IV. Sperm Chromatin Assessment, pp. 45-56

Part V. Sperm Chromatin/DNA Anomalies and Fertility, pp.56-74

Acknowlegements, pp.75

Index, pp.121

      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
   Binding: Softcover
   Pub. Date: 2011
   Pages: 6 x 9
   ISBN: 978-1-61668-194-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Sperm Nuclear Maturation: A Basic and Clinical Approach